Join an excellent team of researchers dedicated to coming closer to the mission of St. Jude Children’s Research Hospital, that no child will die at the dawn of life. Antibody Discovery Collaborative Centre (ADCC) within the Department of Host Microbe Interactions at St. Jude seeks a skilled and highly motivated candidate experienced in antibody discovery.
Candidates with experience in antibody discovery, protein engineering OR expression and validation of biologics are encouraged to apply.
What you will do:
- Antibody discovery with a focus on display methods (phage, yeast, mammalian) and experience in building high-diversity libraries from synthetic and animal repertoires. Integrating ML-based approaches to sequence discovery and engineering with display methods would be preferred.
- Experienced in designing discovery workflows and delivering panel of lead candidates for programs.
- Apply in-vitro display methods for sequence discovery and ability to handle multiple screening arms for antigens.
- Apply NGS methods to mine antibody pools for sequence discovery
- Previous experience in library generation would be vital.
- Develop and optimize high-throughput mammalian cell-based production platforms for recombinant antibodies, antigens, and other biologics
- Work closely with mAb discovery platforms to support molecular biology workflows; design and execute construct generation for antibody expression.
- Perform DNA preparations to generate high-quality plasmid material for mammalian cell transfection.
- Establish scalable transient and stable expression workflows in CHO, HEK293, and other mammalian expression systems.
- Purification using AKTA chromatography systems.
- High-Performance Liquid Chromatography Size Exclusion Chromatography (HPLC-SEC) analysis of purified proteins.
- Molecular assessment of early-stage development candidates (polyreactivity ELISA, CE-SDS, SEC-MALS, DSF)
- Maintain accurate and timely ELN data
Minimum Education and/or Training:
- Bachelor’s degree in a relevant scientific area
Minimum Experience:
- 7 + years of research experience is required
- 5 + years of research experience is required with a Master’s degree
- 2 + years of research experience is required with a PHD
- Experience leading and supporting research experiments preferred
- Some experience leading lab and scientific project coordination, maintenance, and other research support activities preferred
- Experience in guiding and training other laboratory personnel preferred
- Proven performance in earlier role/comparable role
Compensation
In recognition of certain U.S. state and municipal pay transparency laws, St. Jude is including a reasonable estimate of the compensation range for this role. This is an estimate offered in good faith and a specific salary offer takes into account factors that are considered in making compensation decisions including but not limited to skill sets, experience and training, licensure and certifications, and other business and organizational needs. It is not typical for an individual to be hired at or near the top of the salary range and compensation decisions are dependent on the facts and circumstances of each case. A reasonable estimate of the current salary range is $65,520 - $114,400 per year for the role of Associate Scientist Antibody Discovery.
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No Search Firms
St. Jude Children's Research Hospital does not accept unsolicited assistance from search firms for employment opportunities. Please do not call or email. All resumes submitted by search firms to any employee or other representative at St. Jude via email, the internet or in any form and/or method without a valid written search agreement in place and approved by HR will result in no fee being paid in the event the candidate is hired by St. Jude.
