Village of Tarrytown, New York, United States
Hybrid
Regeneron's Product Biochemistry group, located in Tarrytown NY, is seeking an Associate Scientistwho will be responsible for providing in-depth characterization of nucleic acid therapeutics and Lipid Nanoparticles (LNP). In this exciting role, you will be expected to participate in technology innovation efforts aimed at enhancing our understanding of oligonucleotides and LNPs in solution and address both pre-clinical and late-stage program needs.
A Typical Day in the Role of Associate Scientist Might Look Like:
Develop analytical methods and conduct biochemical and biophysical characterization experiments to elucidate quality attributes of gene therapy candidates. Help solve problems in real time.
Provide support for basic research efforts. Ability to adapt and/or optimize methods described in the literature.
Conduct time-sensitive biochemical and extended characterization of siRNAs to meet regulatory timelines.
Provide input on experimental design and suggest method adaptations to address specific needs of a program or attributes of colloidal systems.
Additional responsibilities will include method development of advanced technologies that evaluate the purity and/or thermodynamic and hydrodynamic interactions of siRNAs, mRNAs, CRISPR gRNA and LNP-nucleic acid complexes.
Support forced degradation studies evaluating environmental stressors and their impact on the stability of siRNA, LNPs and their cargos.
Document experiments, results, and findings in electronic laboratory notebook; presents work at group and departmental meetings, contributes to drafting of protocols, method development reports, regulatory submission sections, and peer-reviewed publications.
Maintain instruments, troubleshoots instrumental/experimental problems, and order/maintain supplies.
This Role Might Be For You If You Have:
Excellent oral and written communication skills
Strong initiative and drive to complete challenging tasks with a sense of urgency
Ability and desire to learn new technologies
A desire to work both independently and within a collegial and collaborative environment
BS or MS in Biophysics, Biochemistry, Chemistry, Chemical Engineering, or related field with a minimum of 0-2 years or BS with 2+ years of relevant experience.
A fundamental understanding of practical biophysical chemistry of macromolecules in solution is essential. Basic knowledge of oligonucleotide properties, lipid biochemistry and gene editing therapeutics is important.
Good laboratory practice skills preparing samples, calculating concentrations, documenting, and maintaining cleanliness are critical. Basic practical experience in automated chromatography (FPLC, H/UPLC), spectroscopy (UV-Vis, fluorescence, FTIR and CD) and/or multi-angle/dynamic light scattering (MALS/DLS) of macromolecules is important. Experience with mass spectrometry (MS), NMR, ELSD/CAD, charge-based methods, and/or advanced imaging skills are a bonus. The position is primarily on-site with partially remote (hybrid) schedule.
Does this sound like you? Apply now to take your first step towards living the Regeneron Way! We are committed to building a workplace with an inclusive culture. Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, sexual orientation, gender identity or expression, gender reassignment, marital or civil partnership status, civil status, pregnancy or parental status, age, disability, nationality, citizenship status, ethnic or national origin, membership of the Traveler community, familial status, genetic information, military or veteran status, or any other characteristic protected under applicable law. Where required, we will provide reasonable accommodation to applicants with known disabilities or chronic illnesses during the recruitment process, unless such accommodation would impose undue hardship.
Where necessary, we disclose salary ranges for roles in all countries in which we operate. The final offer will be determined within the relevant range based on the country of employment, specific role level, and your skills and experience. In some countries, collective bargaining agreements (CBAs) may apply and influence certain elements of pay or benefits. Regeneron offers a competitive and comprehensive total rewards package which may include, depending on country and role: annual bonuses or other incentive plans, equity awards, pension or retirement benefits, 401(k) company match, health and wellness programs, fitness centers, insurance benefits (e.g. medical, dental, vision, life and disability), paid time off, and family support benefits. For additional information about Regeneron benefits in the U.S., please visit https://careers.regeneron.com/en/working-at-regeneron/total-rewards/. For other locations, additional information will be provided during the recruitment process. If you have any questions, please speak with your recruiter.
Please be advised that at Regeneron, we believe we do our best work when we are together. For that reason, many roles are required to be performed on‑site. Please speak with your recruiter and hiring manager for more information about on‑site expectations for your role and location.
As part of the recruitment process, certain background checks may be conducted in accordance with the laws of the country where the position is based. The purpose of such checks is to verify certain information prior to the commencement of employment such as identity, right to work and educational qualifications.
For jobs in Canada: this posting is for an existing position.
Salary Range (annually)
$70,300.00 - $110,100.00Want to know if this job is worth applying to?