The Division of Experimental Hematology and Cancer Biology seeks a motivated Associate Staff Scientist. The goal of our laboratory is to develop better therapies to treat patients with acute myeloid leukemia. Patients with acute myeloid leukemia often have an initial response to therapy; however, the disease often reoccurs, and many patients will succumb to this relapsed disease. Not all AML cells are created equally. Indeed, a small subset of cells called leukemia stem cells (LSCs) persist throughout treatment and drive disease relapse. Therefore, it is critically important that we develop new therapies to better target LSCs.
The successful candidate will identify, mechanistically dissect, and therapeutically target metabolic vulnerabilities of leukemia stem cells enriched from primary acute myeloid leukemia and patient derived xenograft models. Techniques used in this research includes culturing of primary AML specimens, flow cytometry analysis and sorting, sample preparation for mass spectrometry, seahorse analysis and functional LSC assays.
JOB RESPONSIBILITIES
Conduct Research - Design, execute and record laboratory experiments; apply standard scientific/research protocols to experiments, research and improve current methods and evaluate innovative techniques. Design and perform experiments and record data according to research protocol. Independently reproduce, evaluate, research and improve techniques currently used. Adapt new methods to existing procedures and modify current experiments through scientific knowledge and intuition. Maintain accurate and detailed records of all laboratory work and experiments. Develop, set-up and verify new procedures in the laboratory. Standardize and establish new published procedures; evaluate innovative techniques. Develop new assays and new protocols; design formats. Discuss relevant insights about experimental results with Director and provide useful recommendations and analysis. Troubleshoot and correct erroneous results or problems with laboratory equipment. Maintain and repair equipment; monitor proper use by personnel. Maintain optimal protocol and assay accuracy by conducting regular quality and reproducibility checks. Demonstrate performance at work, consistency in carrying out instructions, accuracy & attention to detail, achieving expected results & continuous improvement.
Publish - Draft, write and edit scientific reports, papers, journal articles and abstracts. Present at local, national and international scientific meetings.
Teamwork - Train and supervise the work of other laboratory personnel as appropriate. Maintain an integral role in the laboratory's meetings, presentations and publications. Present information on research and laboratory work to others at laboratory meetings, journal clubs and seminars. Demonstrate attendance and punctuality, ability to work independently & display initiative and dedication
Financial Management - Assist in preparing, writing and maintaining fiscal budget. Monitor expenditures and prepare capital expenditure requests. Prepare, approve and initiate check requests; track funding, maintain accurate balance and resolve any discrepancies.
Leadership - May act as a mentor to more junior staff, serve as the contact for resolution of complex issues, provide education, guidance and work direction. May provide input and feedback to managers on hiring decisions, professional development and performance management.
JOB QUALIFICATIONS
PhD
3+ years of work experience in a related job discipline
Primary Location
Location S
Schedule
Full time
Shift
Day (United States of America)
Department
EH&CanBio - Exp Hem
Employee Status
Regular
FTE
1
Weekly Hours
40About Us
At Cincinnati Children’s, we come to work with one goal: to make children’s health better. We believe in a holistic team approach, both in caring for patients and their families, and in advancing science and discovery. We strive to do better and find energy and inspiration in our shared purpose. If you want to be the best you can be, you can do it at Cincinnati Children’s.
Cincinnati Children's is:
Recognized by U.S. News & World Report as a top 10 best Children's Hospitals in the nation for more than 15 years
Consistently among the top 3 Children's Hospitals for National Institutes of Health (NIH) Funding
Recognized as one of America’s Best Large Employers (2025), America’s Best Employers for New Grads (2025)
One of the nation's America’s Most Innovative Companies as noted by Fortune
Consistently certified as great place to work
A Leading Disability Employer as noted by the National Organization on Disability
Magnet® designated for the fourth consecutive time by the American Nurses Credentialing Center (ANCC)
We Embrace Innovation—Together. We believe in empowering our teams with the tools that help us work smarter and care better. That’s why we support the responsible use of artificial intelligence. By encouraging innovation, we’re creating space for new ideas, better outcomes, and a stronger future—for all of us.
Comprehensive job description provided upon request.
Cincinnati Children’s is proud to be an Equal Opportunity Employer committed to creating an environment of dignity and respect for all our employees, patients, and families. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, age, genetic information, national origin, sexual orientation, gender identity, disability or protected veteran status. EEO/Veteran/Disability