Want to know if this job is worth applying to?
Dublin, Éire / Ireland
Hybrid
JOB SUMMARY
Iambic Therapeutics is seeking a Biological Structures Data Engineer to join the NeuralPLexer team and own the data pipelines for acquiring, curating, and transforming experimental and synthetic data to train the next generation of NeuralPLexer models.
This role centers on deep, practical fluency with structural data: .cif files, the PDB, and the work of integrating structural data from many different sources which typically requires careful adaptation before it is usable. Working alongside ML scientists, you will design, implement, and harden the workflows that prepare experimental structural (e.g., protein–ligand complexes) and affinity data for training, and help create and ingest large volumes of high-quality computationally generated synthetic data.
The emphasis throughout is on turning detailed domain knowledge into well-engineered, maintainable infrastructure that the rest of the team can depend on, rather than bespoke one-off handling. This position will be hybrid in our Dublin office.
KEY RESPONSIBILITIES
Understand, maintain, and enhance existing data pipelines, including parsing and validation of structural data (.cif/PDB and beyond)
Integrate and adapt data from a range of public and proprietary sources into reliable, reusable pipelines
Work closely with ML scientists to ensure their data needs are met
Ensure all data is stored in a secure, robust, and retrievable manner
Perform code reviews and exemplify software engineering best practices.
Communicate technical work effectively across a cross-functional research and engineering team
QUALIFICATIONS
Required
Engineer I: PhD or equivalent experience in Bioinformatics, Computational Biology, Cheminformatics or a related field
Engineer II: PhD or equivalent experience in Bioinformatics, Computational Biology, Cheminformatics or a related field with 3+ years of relevant experience
Hands-on familiarity with structural biology data — .cif files, the PDB, and the practical challenges of working with real-world molecular structures
Strong software engineering practices, with a focus on maintainable, well-tested systems
Proficiency in Python
Comfortable operating in a research-driven environment; developing, learning, and adapting cutting edge technologies
Strong collaboration skills and the ability to communicate across a cross-functional research and engineering team
Preferred
Experience designing data pipelines or data infrastructure for heterogeneous or large-scale datasets
Familiarity with additional drug-discovery-relevant data types
Experience contributing to a data lake or comparable centralized data platform
Familiarity with auxiliary data or data transformations relevant to protein structure prediction
Exposure to cloud-based systems (e.g., AWS, Kubernetes) and/or HPC
Background bridging science and software engineering
ABOUT IAMBIC THERAPEUTICS
Iambic is a clinical-stage life-science and technology company developing novel medicines using its AI-driven discovery and development platform. Based in San Diego and founded in 2020, Iambic has assembled a world-class team that unites pioneering AI experts and experienced drug hunters. The Iambic platform has demonstrated delivery of new drug candidates to human clinical trials with unprecedented speed and across multiple target classes and mechanisms of action. Iambic is advancing a pipeline of potential best-in-class and first-in-class clinical assets, both internally and in partnership, to address urgent unmet patient need. Learn more about the Iambic team, platform, pipeline, and partnerships at iambic.ai.
MISSION & CORE VALUES
Our mission is to deliver better medicines through innovations in AI-based discovery technologies. The culture and work at Iambic Therapeutics are profoundly strengthened by the diversity of our people and our differences in background, culture, national origin, religion, sexual orientation, and life experiences. We are committed to building an inclusive environment where a diverse group of talented humans work together to discover therapeutics and create technologies.
PAY AND BENEFITS
We offer a competitive compensation package, pension contributions, and holiday allowances to our team. Our Ireland office provides a modern and collaborative work environment.