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Emeryville, California, United States
Hybrid
Astera is a private foundation on a mission to steer science and technology toward a better future. We believe the coming years will bring an era of unprecedented scientific and technological advancement as exponential progress in AI converges with central advances in other fields to accelerate innovation. This inflection point provides an unparalleled opportunity to fundamentally rethink the institutions, systems, and tools that drive progress. We have committed a $3.5B endowment to that work and fit the form of our support to the function it serves: grants, investments, and in-house research programs. We accept meaningful risk in the research we back and expect some of it to fail because transformative ideas are rarely the ones already proven. Our projects, and the foundation itself, operate like high-velocity startups, with a high performance bar and competitive compensation to match. We are searching for leaders who are compelled by the challenge of driving high-impact change in the way science is funded, conducted, and communicated. You can read more about our mission, vision, and programming at astera.org/vision.
The Astera Institute is seeking a Computational Chemistry / Theory Consultant to provide the specialist molecular-simulation and theory for a nanoscale electrostatic actuator — the electrostatics that drive it and the mechanics of its moving parts (charged plate, force transmitter, and amplifying linkage) — and predict the experimental quantities the team measures on the bench. This position reports to Dr. Jeremy Barton (Astera Institute Resident, Project Lead). This is a contract position.
Model electrostatic actuation — how an applied field drives the charged DNA-origami plate through an ionic solution and into a polymer cushion — using appropriate methods (e.g., Poisson–Boltzmann, explicit-ion molecular dynamics, or continuum modeling) to predict the device's voltage–displacement and force behavior.
Model the actuator's nanomechanics: the stiffness and mechanical modes of the plate, force transmitter, and amplifying linkage, and the coupled electro-mechanical response.
Predict single-molecule fluorescence (FRET) distances, expected structural geometry (for cryo-EM comparison), operational force-distance-voltage surfaces, and surface-attachment energetics, giving the experimental team a quantitative theoretical baseline.
Deliver prediction-versus-measurement comparison reports that flag where the device diverges from theory and guide the next design iteration.
PhD-level expertise in molecular simulation and interfacial electrostatics (e.g., Poisson–Boltzmann, explicit-ion molecular dynamics, or continuum methods) and in nanomechanics, ideally at bio–inorganic interfaces.
Judgment about which method fits which question — in particular, when coarse-grained structural models are and are not adequate for electrostatics.
Demonstrated experience predicting experimental observables (fluorescence, force spectroscopy, electrostatics) and validating them against measurement.
Availability for a project-based contract engagement from the program's start, working closely with the design and device-physics leads.
This position is hybrid at our office in Emeryville, CA. Some travel may be required from time-to-time for in-person collaboration and work.
This is a contract engagement. Compensation is a competitive contract rate, commensurate with experience and the agreed scope and duration of work.
Surprising problem-solver – you love finding unexpected solutions to problems we don't even know we have, and see options where others only see constraints.
Bias to action – you launch and iterate on thoughtful experiments rather than waiting for perfect plans, and you're energized by novel problems.
High standards, internally driven – you hold yourself to the bar of building world-class public goods without benchmarking against others.
Operate with the highest levels of integrity, judgment, and stewardship – you treat residents, peers, and vendors with genuine respect for their time and contributions.
Embrace the tools that define great work today – Astera is building for an AI-driven future and equips the team accordingly; we see these as genuine force multipliers, not optional extras.
