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South San Francisco, California, United States
Hybrid
Maze's Chemical Development team manages the manufacture of drug substance (DS) for Maze's clinical programs. The team develops, optimizes, and scales chemical manufacturing processes so that reactions run safely, effectively, and economically from bench to clinic.
As Manager, Chemical Development, you will manage external contract manufacturing organizations (CMOs) that manufacture and test drug substance and starting materials (SM). You will work closely with Maze's discovery teams, for example medicinal chemistry, drug metabolism and pharmacokinetics (DMPK), and pharmacology, to carry candidates smoothly from preclinical work into manufacturing. You will also partner with Quality Assurance and Regulatory Affairs to keep Maze's manufacturing compliant with current good manufacturing practices (cGMPs) and federal regulations.
This is a role for someone who wants direct ownership of how a molecule becomes a manufacturable drug substance, with visibility across discovery, quality, and regulatory functions at a clinical-stage company.
Because this role works closely with international CMOs, meetings outside standard business hours may be required to accommodate global time zones. Domestic and international travel will also be required based on program and CMO needs.
Maze Therapeutics is a clinical-stage biopharmaceutical company harnessing human genetics to develop precision medicines for patients with kidney and metabolic diseases. Our clinical pipeline is anchored by two small molecule programs: MZE829, an APOL1 inhibitor for patients with APOL1‑mediated kidney disease, and MZE782, which targets genetic drivers of disease in phenylketonuria (PKU) and chronic kidney disease. We are also advancing a preclinical pipeline through our Compass platform, which links human genetic variants to the biological pathways that drive disease.
Maze is comprised of a team of passionate and creative professionals committed to discovering and delivering transformative medicines to patients suffering from both rare and common genetic diseases. We are fostering a culture that encourages vision, initiative and the development of talent. Our supportive work environment inspires creative thinking and freedom of expression, resulting in a stimulating atmosphere where people enjoy coming to work. While we have a passion for advanced science and pride ourselves on excellence in execution, ultimately, everything we do is about patients.
Our Core Values
Further Together – Our path is paved with challenges, but with resilience and a team-first mentality, we’ll achieve our mission.
Impact Obsessed – We embrace the bold, take calculated risks, and learn from our mistakes to improve the lives of others.
Stand True – Our integrity is foundational; it guides us no matter the obstacle.
The expected annual salary range for employees located in the San Francisco Bay Area is $158,000 - $193,000. Additionally, this position is eligible for an annual performance bonus.
Maze performs position-based compensation benchmarking to industry market data to ensure we pay competitive wages. Determination of starting salary will depend upon a variety of job-related factors, which may include professional experience, skills, and job location. The expected salary range for this role may be modified in the future.
Maze offers a robust benefits package to our eligible employees including competitive medical, dental, and vision insurance, mental health offerings, equity incentive plan, 401(k) program with employer match and a generous holiday and PTO policy.
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