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Boston, Massachusetts, United States
Onsite
Centessa Pharmaceuticals, a wholly owned subsidiary of Eli Lilly and Company, is a clinical-stage company developing orexin receptor 2 (OX2R) agonists as a new class of medicines for the treatment of narcolepsy and potentially other sleep-wake disorders. Centessa’s lead investigational candidate – cleminorexton (formerly ORX750) – is being developed for narcolepsy type 1, narcolepsy type 2, and idiopathic hypersomnia. Centessa's OX2R agonist portfolio includes additional clinical and preclinical-stage assets with potential utility across a broader range of neurological, neurodegenerative, and neuropsychiatric conditions.
Headquartered in Boston, Massachusetts, Centessa was recognized as a Great Place to Work® in 2026.
Description of Role
The Manager, Product Quality will provide quality oversight and support for product development and manufacturing activities across the Company portfolio. This role is responsible for ensuring quality considerations are integrated throughout the product lifecycle, from clinical development through commercial readiness.
Reporting to the Executive Director, GMP Quality Assurance, this individual will serve as a key quality partner to Technical Operations, CMC Development, Regulatory Affairs, Clinical Supply Chain, and external manufacturing organizations. The role requires strong technical knowledge, sound judgment, and the ability to effectively manage quality activities in a fast-paced, outsourced development environment.
Key Responsibilities
Product Quality Oversight
Manufacturing and Technical Operations Support
Investigations, CAPAs, and Change Controls
Regulatory and Inspection Support
Supplier and CMO Management
Continuous Improvement
Qualifications
Work Location
The Manager, Product Quailty role is based in the US, with occasional travel.
Compensation
The annual base salary range for this position is $105,000.00 to $150,000.00. Individual compensation within this range will be determined based on a variety of factors, including qualifications, skills, relevant experience, job knowledge an location.
In addition to base pay, this role is eligible for a discretionary annual bonus. The Company also offers a comprehensive benefits package, which includes a 401(k) plan, company-sponsored medical, dental, vision, and life insurance, generous paid time off, and a health and wellness program.
POSITION: Full-Time, Exempt
EEOC Statement: Centessa Pharmaceuticals, a wholly owned subdisary of Eli Lilly and Company believes in a diverse environment and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion, or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. We will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
Please note: We will not assign referral rights for any unsolicited resumes from recruitment agencies.
