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Boston, Massachusetts, United States
Onsite
Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not-for-profit, we support patient care, research, teaching, and community service, striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham.
Job Summary
The BioTranslation Lab is strongly focused on translational research: we develop materials and delivery technologies that address unmet medical needs and improve patients' lives. Based at Brigham and Women's Hospital and Harvard Medical School, and affiliated with the Broad Institute of MIT and Harvard, we work across chemistry, materials science, biology, engineering, and medicine to advance promising technologies from fundamental design and mechanistic investigation through in vivo validation and toward clinical application.
Qualifications
POSITION 1 | Chemistry & Materials Science for Long-Acting Therapeutics
Lead project design and execution, including the synthesis and characterization of novel materials and formulation strategies for long-acting injectable and implantable delivery systems. Potential applications include infectious-disease prevention and treatment, substance use disorder, hormonal therapy, and organ transplantation.
Core qualification
Ph.D. or equivalent in chemistry, bioengineering, chemical engineering, materials science, polymer science, pharmaceutical sciences, or a related field.
Experience in one or more of the following would be valuable
Polymer synthesis and characterization
Controlled-release formulations or long-acting drug-delivery systems
Release kinetics, degradation, mechanical or rheological characterization, and relationships to in vivo performance
Scalable and manufacturable formulation or fabrication processes
In vitro and in vivo pharmacokinetic evaluation
POSITION 2 | Non-Viral Delivery of Gene Therapies and Gene-Editing Tools
Lead the engineering and evaluation of lipid nanoparticles, polymeric carriers, and other non-viral systems for RNA therapeutics, gene therapies, and gene-editing tools such as CRISPR/Cas systems. Projects will address delivery efficiency, tissue and cell targeting, and safety in the brain, lung, and other difficult-to-reach tissues.
Core qualification
Ph.D. or equivalent in bioengineering, chemical engineering, molecular biology, pharmaceutical sciences, or a related field.
Experience in one or more of the following would be valuable
Non-viral delivery of nucleic acids, including mRNA, siRNA, or CRISPR/Cas components
Nanoparticle formulation and physicochemical characterization
Targeting, biodistribution, or pharmacokinetic studies
In vitro and in vivo efficacy studies, including expression, knockdown, or editing readouts
Adapting delivery technologies to new tissues and therapeutic targets
POSITION 3 | Immunology and Immunoengineering
Lead mechanistic studies defining the immunological dimensions of BTL's therapeutic platforms, including immunomodulation, neuroinflammation, and host responses to biomaterials and delivery systems. The goal is to use these insights to improve therapeutic safety and efficacy.
Core qualification
Ph.D. or equivalent in immunology, microbiology, molecular or cellular biology, or a related field. Prior experience in materials science or drug delivery is welcome but not required.
Experience in one or more of the following would be valuable
Immune responses to biomaterials, nanoparticles, or delivery platforms
Experimental models of immunomodulation or neuroinflammation
Flow cytometry, cytokine profiling, single-cell approaches, or related immunological assays
Mechanistic studies that connect immune responses with therapeutic performance
Close collaboration with materials- and delivery-focused scientists
We welcome candidates who have completed, or are nearing completion of, a Ph.D. or equivalent degree and who combine strong technical foundations with curiosity, creativity, and scientific rigor. Successful fellows take ownership of their work, bring initiative and an entrepreneurial mindset to project development, communicate clearly, and enjoy collaborating across disciplines. A strong publication record is valued, but we will consider accomplishments in the context of each candidate's opportunities, field, and career stage.
Fellows are expected to develop and execute rigorous studies, communicate findings through publications and scientific presentations, contribute positively to the lab community, and pursue opportunities for increasing scientific independence.
The salary for this position ranges from $71,750 to $73,544 annually.
Learn more: www.thejoshilab.com
Additional Job Details (if applicable)
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At Mass General Brigham, our competency framework defines what effective leadership “looks like” by specifying which behaviors are most critical for successful performance at each job level. The framework is comprised of ten competencies (half People-Focused, half Performance-Focused) and are defined by observable and measurable skills and behaviors that contribute to workplace effectiveness and career success. These competencies are used to evaluate performance, make hiring decisions, identify development needs, mobilize employees across our system, and establish a strong talent pipeline.