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Lower Gwynedd Township, Pennsylvania, United States
Onsite
At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at jnj.com.
As guided by Our Credo, Johnson & Johnson is responsible to our employees who work with us throughout the world. We provide an inclusive work environment where each person is considered as an individual. At Johnson & Johnson, we respect the diversity and dignity of our employees and recognize their merit.
Job Function:
Discovery & Pre-Clinical/Clinical DevelopmentJob Sub Function:
Pharmaceutical Product R&DJob Category:
Scientific/TechnologyAll Job Posting Locations:
Cambridge, Massachusetts, United States of America, San Diego, California, United States of America, Spring House, Pennsylvania, United States of AmericaJob Description:
Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.
Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.
Learn more at https://www.jnj.com/innovative-medicine
Johnson & Johnson Innovative Medicine is recruiting for a Principal Scientist, AI-Native Discovery (Large Molecules) to join our In Silico Drug Discovery team. This position will be located in either Spring House, PA (preferred); Cambridge, MA; or San Diego, CA (La Jolla area) and may require some travel as needed. (No remote option.)
The Opportunity
We are seeking a creative, highly collaborative, and self-motivated Principal Scientist to join our In Silico Discovery (ISD), In Silico Biologics team. In this role, you will help shape the future of AI-native biologics discovery by integrating advanced AI, agentic workflows, predictive modeling, and computational design into Therapeutic Discovery programs. You will represent In Silico Discovery on cross-functional project teams, integrating broader ISD capabilities and AI-native approaches.
The ideal candidate combines experience influencing cross-functional discovery programs with therapeutic development expertise and a passion for using AI to generate insights, inform experimental strategies, and improve discovery decisions. You will help build new ways of working that integrate human scientific judgment, machine intelligence, experimental data and computational methods, while leveraging capabilities from across ISD and the broader J&J technical community.
This is an opportunity to join a diverse, global community of in silico scientists and contribute directly to the discovery of innovative medicines for patients.
What You Will Do
How You Will Make an Impact
You will help define how AI becomes an integral part of biologics discovery, enabling new approaches to scientific learning and decision-making.
By connecting human expertise, AI models, computational design, experimental workflows, and high-quality data, you will help create a more predictive, scalable, and adaptive discovery environment. Your work will contribute to faster learning cycles, stronger design decisions, and the advancement of differentiated biologic medicines for patients.
Why Join Us
Required Qualifications
Preferred Qualifications
This position will be located in either Spring House, PA (preferred); Cambridge, MA; or San Diego, CA (La Jolla area) and may require some travel as needed. (No remote option.)
Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act.
If you are under 18 years of age, you (the candidate) may need to obtain the necessary working papers or other documentation required by state law to start the assignment, as well as get a parent’s consent for the background check.
Johnson & Johnson is committed to providing an interview process that is inclusive of our applicants’ needs. If you are an individual with a disability and would like to request an accommodation, external applicants please contact us via https://www.jnj.com/contact-us/careers , internal employees contact AskGS to be directed to your accommodation resource.
The anticipated base pay range for this position is $117,000 to $201,250. The Company maintains highly competitive, performance-based compensation programs. Under current guidelines, this position is eligible for an annual performance bonus in accordance with the terms of the applicable plan. The annual performance bonus is a cash bonus intended to provide an incentive to achieve annual targeted results by rewarding for individual and the corporation’s performance over a calendar/performance year. Bonuses are awarded at the Company’s discretion on an individual basis. Employees and/or eligible dependents may be eligible to participate in the following Company sponsored employee benefit programs: medical, dental, vision, life insurance, short- and long-term disability, business accident insurance, and group legal insurance.
Employees may be eligible to participate in the Company’s consolidated retirement plan (pension) and savings plan (401(k)).
Employees are eligible for the following time off benefits:
Vacation – up to 120 hours per calendar year
Sick time - up to 40 hours per calendar year
Holiday pay, including Floating Holidays – up to 13 days per calendar year of Work, Personal and Family Time - up to 40 hours per calendar year
Additional information can be found through the link below. https://www.careers.jnj.com/employee-benefits
The compensation and benefits information set forth in this posting applies to candidates hired in the United States. Candidates hired outside the United States will be eligible for compensation and benefits in accordance with their local market.
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Required Skills:
Preferred Skills:
Budget Management, Chemistry, Manufacturing, and Control (CMC), Clinical Trial Protocols, Critical Thinking, Cross-Functional Collaboration, Drug Discovery Development, Industry Analysis, Interdisciplinary Work, Market Research, Organizing, Pharmacokinetic Modeling, Process Improvements, Product Development, Product Strategies, Report Writing, Safety-Oriented, Scientific Research.jpg?1732270634){kind=logo}
