Principal Scientist, In-vivo CAR-T

At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at jnj.com.

As guided by Our Credo, Johnson & Johnson is responsible to our employees who work with us throughout the world. We provide an inclusive work environment where each person is considered as an individual. At Johnson & Johnson, we respect the diversity and dignity of our employees and recognize their merit.

Job Function:

Discovery & Pre-Clinical/Clinical Development

Job Sub Function:

Biotherapeutics R&D

Job Category:

Scientific/Technology

All Job Posting Locations:

Malvern, Pennsylvania, United States of America

Job Description:

At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal.

Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at jnj.com.

As guided by Our Credo, Johnson & Johnson is responsible to our employees who work with us throughout the world. We provide an inclusive work environment where each person is considered as an individual. At Johnson & Johnson, we respect the diversity and dignity of our employees and recognize their merit.

We are searching for the best talent for a Principal Scientist, In-vivo CAR-T, to be based on-site in Malvern, PA.

Purpose:

The Principal Scientist will support the development, optimization, and scale-up of lentiviral vector (LVV) drug product processes from early to late-stage development. The role combines hands-on laboratory work with strong cross-functional collaboration to ensure robust, scalable, and GMP-ready processes.

Key Responsibilities:

• Lead, design, and execute LVV process development studies across early and late development stages

• Collaborate with modelling experts and data scientists to identify opportunities where modelling or machine learning can reduce experimental burden, improve robustness, or define process design space.

• Perform hands-on laboratory work including process design, optimization, and characterization

• Analyze and interpret data to support process understanding, optimization, and decision-making

• Support process characterization activities, including identification of CPPs and development of robust processes

• Contribute to scale-up and manufacturing readiness, including support of technology transfer to internal sites or CMOs

• Collaborate cross-functionally with Analytical Development, MSAT, Quality, Manufacturing, and Regulatory teams to ensure alignment on process strategy and execution

• Document experimental work and results in accordance with GxP and data integrity requirements

• Participate in troubleshooting activities and continuous process improvement initiatives

Qualifications:

Required:

• Ph.D. 2-4 years’ experience, B.S. or M.S. with 6-8 years of experience in an appropriate scientific discipline (Life Sciences or Chemical Engineering) is required

• Relevant experience in process development of viral vectors and/or LVV formulation development

• Strong hands-on laboratory experience in drug product or viral vector development

• Understanding of process scale-up, technology transfer, and GxP principles

• Ability to manage/collaborate in a matrix environment

• Strong scientific problem-solving and data interpretation skills

• Hands-on, proactive, and detail-oriented approach

• Ability to work effectively in a cross-functional, matrixed environment

• Clear and concise communication skills (written and verbal)

• Ability to manage multiple priorities in a dynamic development environment

Preferred:

• Experience with LVV platforms, viral vectors and/or advanced therapies

• Familiarity with process validation (e.g., LCPV) and manufacturing support

• Exposure to both early and late-stage development or commercial readiness activities

Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act.

Johnson and Johnson is committed to providing an interview process that is inclusive of our applicants’ needs. If you are an individual with a disability and would like to request an accommodation, please email the Employee Health Support Center (ra-employeehealthsup@its.jnj.com) or contact AskGS to be directed to your accommodation resource.

 

 

Required Skills:

 

 

Preferred Skills:

Analytical Reasoning, Biochemistry, Biotechnology, Chemistry, Manufacturing, and Control (CMC), Clinical Research and Regulations, Clinical Trial Designs, Coaching, Critical Thinking, Drug Discovery Development, Emerging Technologies, Molecular Diagnostics, Organizing, Pharmacovigilance, Presentation Design, Process Improvements, Productivity Planning, Scientific Research