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Waltham, Massachusetts, United States
Onsite
Job title: Process modelling (Protein/Antigen) Principal Data Scientist
Location: Waltham, MA
About the Job
As Principal Data Scientist within our Process Modeling – Vaccines R&D Data & Computational Science team, you'll lead the development of AI, machine learning, and hybrid modeling solutions that accelerate the future of recombinant protein vaccine manufacturing. Ready to get started?
Join the team protecting half a billion lives every year with next-gen science, mRNA innovation, and AI-driven breakthroughs. In Vaccines, you'll help advance prevention on a global scale - and shape the future of immunization.
Join the engine of Sanofi's mission — where deep immunoscience meets bold, AI-powered research. In R&D, you'll drive breakthroughs that could turn the impossible into possible for millions. In this role, you'll work closely with process development, analytical, and manufacturing teams to improve process understanding and optimize performance across CHO cell culture, baculovirus expression systems, protein purification, and cell line development. You'll bring scientific rigor and computational innovation together to enable data-driven decisions that strengthen how we develop and manufacture life-saving vaccines.
About Sanofi
We're an R&D-driven, AI-powered biopharma company committed to improving people's lives and delivering compelling growth. Our deep understanding of the immune system – and innovative pipeline – enables us to invent medicines and vaccines that treat and protect millions of people around the world. Together, we chase the miracles of science to improve people's lives.
Main Responsibilities
• Lead the development and deployment of AI, machine learning, mechanistic, and hybrid modeling solutions to accelerate recombinant protein vaccine process development and manufacturing.
• Apply advanced analytics to identify critical process parameters, predict product quality, improve yield, and optimize process performance.
• Develop modeling solutions for upstream processes, including CHO cell culture, baculovirus and insect cell expression systems, and cell line development.
• Support optimization of downstream purification operations, including chromatography, filtration, and ultrafiltration/diafiltration, through data-driven and model-based approaches.
• Build and deploy digital twins, simulation tools, and decision-support frameworks to support process optimization, scale-up, technology transfer, and lifecycle management.
• Collaborate with process development, analytical sciences, manufacturing, and digital teams to integrate process knowledge and data into actionable insights.
• Provide scientific leadership and mentorship in AI, machine learning, data science, and process modeling across the organization.
About You
Basic Qualifications
Education
Experience
Preferred Qualifications
Languages: Fluent English required.
Why Choose Us?
Sanofi US Services and its U.S. affiliates are Equal Opportunity employers committed to a culturally inclusive workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.
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Better is out there. Better medications, better outcomes, better science. But progress doesn’t happen without people – people from different backgrounds, in different locations, doing different roles, all united by one thing: a desire to make miracles happen. So, let’s be those people.
Sanofi US endeavours to make our career center accessible to any and all users. If you are experiencing difficulty and need assistance applying online, please call 1-866-SANOFI2 (1-866-726-6342) or click here
US and Puerto Rico Residents Only
Sanofi Inc. and its U.S. affiliates are Equal Opportunity employers committed to a culturally inclusive workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.
North America Applicants Only
The salary range for this position is:
$122,250.00 - $176,583.33All compensation will be determined commensurate with demonstrated experience. Employees may be eligible to participate in Company employee benefit programs, and additional benefits information can be found here.
