Band
Level 2
Job Description Summary
Over 40 therapies in the clinic! NIBR Oncology strives to reimagine medicines for cancer patients through a combination of treatment approaches including targeted therapies, immunotherapies, CAR-T, and radioligand therapy. NIBR is seeking a lab-based in vivo scientist to join our Oncology Pharmacology team in Cambridge, MA. The successful candidate will join a dynamic, multi-disciplinary team and play a key role in the development and application of in vivo models for evaluating novel cancer therapies and advancing the early-stage drug discovery pipeline. The primary responsibility of this position will be to execute in vivo anti-tumor efficacy and PK/PD studies aimed at evaluating novel drug candidates in CDX, PDX, and syngeneic models. Applicants are expected to spend the majority of their time in the lab. Qualified candidates will be proficient in animal handling techniques and compound administration, while possessing a variety of molecular biology and flow cytometric skills. We are looking for highly motivated, inquisitive, and creative individuals, who thrive in a highly-matrixed work environment, and can effectively communicate within multidisciplinary project teams.
Job Description
Responsibilities:
Hands-on execution of pre-clinical in vivo studies to explore novel hypotheses, screen candidate molecules, and establish proof-of-concept
Develop in vivo CDX, PDX, and syngeneic models to evaluate anti-tumor activity, PK/PD relationships, and relevant biomarkers of novel compounds to support clinical development
Work independently and in collaboration with other colleagues in pharmacology to execute studies
Critically analyze and present results within a multidisciplinary team environment
Careful adherence to animal protocols and proper documentation of data and methods in electronic laboratory notebook
Qualifications:
Research Scientist I position: BS/MS in biological sciences with 2+ years of relevant research experience in pharmaceutical/biotech industry
Research Scientist II position: BS/MS in biological sciences with 4+ years of relevant research experience in pharmaceutical/biotech industry
Extensive experience working with CDX and PDX xenograft tumor models and/or syngeneic models
Experience with cell culture
Hands-on mouse/rat handling skills, including dosing (IV, IP, PO), tumor implantation, caliper tumor measurements, xenogen imaging, and blood/tissue collection techniques
Experience with PCR, ELISA, western blot, and flow cytometry
Strong analytical, communication (written and verbal), and organizational skills, including a proficiency with PowerPoint and commonly used data analysis programs, such as Excel and Prism
Novartis Compensation and Benefit Summary:
The salary for this position is expected to range between:
Research Scientist I: $66,800 - $124,000 per year.
Research Scientist II: $81,200 - $150,800 per year
The final salary offered is determined based on factors like, but not limited to, relevant skills and
experience, and upon joining Novartis will be reviewed periodically. Novartis may change the published
salary range based on company and market factors.
Your compensation will include a performance-based cash incentive and, depending on the level of the
role, eligibility to be considered for annual equity awards.
US-based eligible employees will receive a comprehensive benefits package that includes health, life and
disability benefits, a 401(k) with company contribution and match, and a variety of other benefits. In addition, employees are eligible for a generous time off package including vacation, personal days, holidays and other leaves.
EEO Statement:
The Novartis Group of Companies are Equal Opportunity Employers. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.
Accessibility and reasonable accommodations
The Novartis Group of Companies are committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or in order to perform the essential functions of a position, please send an e-mail to tas.nacomms@novartis.com call +1 (877)395-2339 and let us know the nature of your request and your contact information. Please include the job requisition number in your message.
https://www.novartis.com/careers/careers-research/notice-all-applicants-us-job-openings
Salary Range
$81,200.00 - $150,800.00
Skills Desired
Algorithms, Algorithms, Analytical Skill (Inactive), Analytical Thinking, Chemical Biology, Clinical Research, Clinical Trials, Collaboration, Communication Skills (Inactive), Curious Mindset, Data (Inactive), Data Analysis, Design of Experiments (DOE), Detail-Oriented, Diversity and Inclusion (D&I), Drug Discovery Process, Ethics, Hypothesis Testing, Immunology, Laboratory (Inactive), Leading Project Teams, Lifesciences (Inactive), Mammalian Cell Culture, Medical Research, Molecular Biology {+ 6 more}