Scientist, Protein Sciences - San Carlos, California

BeOne continues to grow at a rapid pace with challenging and exciting opportunities for experienced professionals. When considering candidates, we look for scientific and business professionals who are highly motivated, collaborative, and most importantly, share our passionate interest in fighting cancer.

General Description:

At BeOne Institute, we extend BeOne’s execution strength with a dedicated innovation engine, bringing agility and scientific depth to transform uncertainty into actionable and high-impact therapeutic opportunities. We operate according to three core principles:  

• Bold Exploration: we pursue novel and high-potential ideas through rapid, iterative innovation cycles. 

• Strategic Alignment: we prioritize disease areas that align closely with BeOne’s R&D priorities and long-term vision. 

• Pipeline Impact: we translate insights into tangible assets and advance emerging platforms into impactful programs. 
   

As a Scientist at BeOne Institute, you will play a key role in enabling cutting-edge research at our San Carlos, CA site by delivering high-quality recombinant proteins for a broad range of applications, including tool antibodies, enzymes, screening reagents, and structural biology studies. You will develop and implement innovative approaches to improve the quality, scalability, turnaround time, and success of recombinant protein production workflows. In addition, you will contribute creatively to research programs across the site, collaborating with multidisciplinary teams to advance novel scientific initiatives and enable new discoveries.

Essential Functions of the Job:

• Design, express, and purify proteins utilizing bacterial and mammalian expression systems.
• Produce a wide range of protein reagents, including antibodies, enzymes, transcription factors, membrane proteins, and others.
• Generate QC data and maintain reference lots when appropriate (experience with anSEC and LC/MS a plus).
• Keep track of lot IDs, plasmids, and protein inventories.
• Communicate progress through regular updates while proactively identifying challenges and proposing solutions.
• Collaborate with cross-disciplinary or cross-functional teams and drive innovation within and beyond the Institute.
• Contribute to operational activities to support strategic objectives of the BeOne Institute at the San Carlos site.
• Maintain impeccable ELN records.
• Stay current on state-of-the-art protein production and purification technologies and methods as well as project-relevant literature.

Supervisory Responsibilities:  

• May be a contact for external CRO partners when needed
• May provide matrix or line-function leadership for project teams when needed

Computer Skills:   

• Candidates are expected to maintain an electronic notebook to a high level of data quality
• Familiarity with Unicorn software is required
• Familiarity with AlphaFold and/or other protein design tools is a plus

Required Qualifications:   

• Degree in biology, chemistry, engineering, or other related field (Ph.D. + 2 years of experience, MS + 5 years of experience, or BS + 8 years of experience)
• Deep expertise in bacterial and mammalian expression systems
• Deep experience in protein purification utilizing affinity chromatography, ion exchange chromatography, size exclusion chromatography, and other methods, including the use of AKTA FPLC systems
• Experience with construct design and synthesis
• Ability to operate effectively in a highly collaborative, fast-paced, and interdisciplinary research environment, and to integrate multi-disciplinary approaches to solve complex biological problems
• Excellent communication and presentation skills, with the ability to clearly articulate complex scientific concepts to both technical and non-technical audiences
• Be able to work on-site in San Carlos, CA

Preferred Qualifications:

• Experience in a drug discovery setting
• Experience with endotoxin-free protein production and endotoxin-removal workflows
• Working knowledge of protein structure determination methods, including X-ray crystallography (XRC), cryo-electron microscopy (cryo-EM), and/or biomolecular NMR (bioNMR)
• Experience with HPLC and mass spectrometry
• Experience with insect cell, yeast, cell-free, or other alternative protein expression systems

Education Required:

BS + 8 years of experience
MS  + 5 years of experience

PhD + 2 years of experience

Travel:  None

Global Competencies

When we exhibit our values of Patients First, Driving Excellence, Bold Ingenuity and Collaborative Spirit, through our twelve global competencies below, we help get more affordable medicines to more patients around the world.

• Fosters Teamwork
• Provides and Solicits Honest and Actionable Feedback
• Self-Awareness
• Acts Inclusively
• Demonstrates Initiative
• Entrepreneurial Mindset
• Continuous Learning
• Embraces Change
• Results-Oriented
• Analytical Thinking/Data Analysis
• Financial Excellence
• Communicates with Clarity

Salary Range: $136,600.00 - $170,700.00 annually

BeOne is committed to fair and equitable compensation practices. Actual compensation packages are determined by several factors that are unique to each candidate, including but not limited to job-related skills, depth of experience, certifications, relevant education or training, and specific work location. Packages may vary by location due to differences in the cost of labor. The recruiter can share more about the specific salary range for a preferred location during the hiring process.  Please note that the listed range reflects the base salary or hourly range only. Non-Commercial roles are eligible to participate in the annual bonus plan, and Commercial roles are eligible to participate in an incentive compensation plan. All Company employees have the opportunity to own shares of BeOne Medicines Ltd. stock because all employees are eligible for discretionary equity awards and to voluntarily participate in the Employee Stock Purchase Plan. The Company has a comprehensive benefits package that includes Medical, Dental, Vision, 401(k), FSA/HSA, Life Insurance, Paid Time Off, and Wellness.

We are proud to be an equal opportunity employer. BeOne does not discriminate on the basis of race, religion, color, sex, gender identity, sexual orientation, age, disability, national origin, veteran status or any other basis covered by appropriate law. All employment is decided on the basis of qualifications, merit, and business need. In order to ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Era Veterans’ Readjustment Assistance Act of 1974, Title I of the Americans with Disabilities Act of 1990, and any other applicable federal, state or local laws, applicants who require reasonable accommodation in the job application process may contact accommodationsus@beonemed.com.