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USA - Pennsylvania - Upper Providence, United States of America
Hybrid
Job Title: Senior Director, Portfolio Integration Lead - Hematology
Description
For candidates seeking to be located at our Stevenage site, this role will temporarily be based at Stevenage. However, the Company plans to relocate its offices to Cambridge, UK. The location of this role will therefore subsequently change to Cambridge, UK in accordance with timelines to be set by the Company. The relocation is currently proposed to take effect by early 2029.
Overview
Cancer is unrelenting, but so are we. At GSK, we are committed to transforming outcomes for people with cancer through innovative science, bold ambition, and strong partnerships across the healthcare ecosystem. We focus our science where it can matter most - advancing care in cancers with high unmet need, grounded in a deep understanding of disease biology and deliberate scientific choices that connect discovery to meaningful impact in the real world.
The Portfolio Integration Lead (PIL) is a senior role in Oncology Clinical Development, responsible for shaping the advancement of multiple oncology programmes from our portfolio with a focus on particular cancers. Working closely with both the VP and Clinical Development Leads (CDLs) and cross-functional teams across GSK, this role ensures scientific alignment, portfolio coherence, and development excellence across assets. This is a senior individual contributor position that operates across the full breadth of an Oncology portfolio rather than within a single programme, enabling cross-asset integration and strategic alignment across development activities.
The PIL applies a disease-level clinical and scientific lens across the portfolio, integrating disease biology, biomarker strategy, and emerging clinical approaches to define what is scientifically feasible and inform development pathways across programmes. This includes bringing clinical context to novel biomarker strategies and trial designs, particularly for early-stage and mechanistically novel assets and across programmes with similar indications.
The position is open to candidates from either a medical or non-medical background based on the expertise required to be successful operating at the intersection of oncology disease strategy, clinical development, and portfolio leadership.
In This Role You Will:
Provide senior scientific partnership to CDLs, particularly in areas such as disease biology, biomarker strategy, and novel treatment combinations development.
Ensure consistent cross-programme ways of working to improve development efficiency and execution.
Drive cross-programme portfolio working groups and ensure business level alignment
Drive and support clinical trial innovation based on evolving oncology treatment landscape, government regulations, basic/translational science, and emerging technologies (such as AI-enabled tools).
Strengthen the scientific and strategic positioning of a pan-asset portfolio across multiple clinical and pre-clinical assets.
Drive initiatives that advance data and technology strategies supporting development decision-making.
Shape engagement with external experts and governance bodies including advisory boards where relevant.
Key Responsibilities
Portfolio Strategy & Cross-Program Integration
Shape the advancement of multiple development programs within the oncology portfolio by providing scientific insights across assets, ensuring that agreed disease strategy is implemented consistently across programs.
Prepare detailed strategic analyses and portfolio recommendations on behalf of the Disease Area Vice President, enabling effective decision-making at senior leadership and governance levels.
Ensure alignment and coordination across Clinical Matrix Teams (CMTs) and relevant cross-functional stakeholders in Research & Development (R&D), Global Medical Affairs (GMA) and Global Product Strategy (GPS).
Drive disease-level strategic discussions and portfolio planning, bringing a pan-asset perspective to governance discussions and portfolio prioritization.
Serve as a subject matter expert supporting global health authority interactions, regulatory submissions and key development milestones across multiple assets.
Partnership with Clinical Development Leads
Serve as a scientific thought partner to CDLs across multiple asset programs, shaping key aspects of clinical development strategy for a given tumour types, including:
disease biology and translational science
biomarker and precision medicine approaches
combination strategies
emerging clinical development opportunities
Clinical Development Excellence
Establish and champion consistent ways of working across programs to improve efficiency and development quality.
Drive innovation in clinical development approaches for a given disease area, including trial design, novel endpoints, and emerging technologies such as AI-enabled analytics where appropriate.
External Scientific Engagement
Maintain a deep understanding of the evolving tumour disease landscape, standards of care, and emerging science.
Shape engagement with external experts through advisory boards.
Synthesise portfolio-level external insights to inform and strengthen development strategy across multiple programs.
Data & Innovation Strategy
Drive initiatives that strengthen the application of data, technology, and analytics in clinical development decision-making for a given tumour type.
Champion innovative approaches to clinical trials and portfolio insights, ensuring the tumour portfolio remains at the forefront of emerging capabilities.
Basic Qualifications:
Bachelor’s / Master’s / Advanced degree in a scientific or medical discipline. Candidates may come from a medical or scientific background; oncology drug development expertise with defined experience is expected.
10+ years of experience in oncology drug development within pharmaceutical or biotechnology environments, including involvement across multiple programs or assets.
Experience of clinical development processes, regulatory pathways, and oncology therapeutic landscapes.
Experience in operating structured matrix organizations and demonstrate decision-making and stakeholder engagement at senior organizational levels.
Preferred Qualifications:
Experience as a Clinical Development Lead, Medical Director, Clinical Scientist Program Lead, or equivalent program leadership role in oncology.
Expertise in biomarker development, precision medicine strategies, or combination therapy approaches.
Experience engaging with external scientific experts, advisory groups, and Health Authorities.
Demonstrated ability to influence senior stakeholders and shape strategic portfolio discussions.
Familiarity with clinical trial innovation methods, including AI/ML applications, adaptive trial designs, or real-world evidence integration.
Work Arrangement: This role offers a hybrid working model, with a mix of on-site and remote work. Remote or fully home-working arrangements are not available for this role.
Skills
Clinical Data Interpretation, Clinical Trial Designs, Clinical Trials Monitoring, Digital Fluency, Drug Development, Drug Regulatory Affairs, Evidence Based Decision Making, Executive Presence, Hematology and Oncology, Learning Agility, Matrix Leadership, Real World Evidence (RWE), Scientific Presentations, Strategic Direction
• If you are based in Cambridge, MA; Waltham, MA; Rockville, MD; or San Francisco, CA, the annual base salary for new hires in this position ranges $242,250 to $403,750. The US salary ranges take into account a number of factors including work location within the US market, the candidate’s skills, experience, education level and the market rate for the role. In addition, this position offers an annual bonus and eligibility to participate in our share based long term incentive program which is dependent on the level of the role. Available benefits include health care and other insurance benefits (for employee and family), retirement benefits, paid holidays, vacation, and paid caregiver/parental and medical leave. If salary ranges are not displayed in the job posting for a specific country, the relevant compensation will be discussed during the recruitment process.
Please visit GSK US Benefits Summary to learn more about the comprehensive benefits program GSK offers US employees.
Why GSK?
Uniting science, technology and talent to get ahead of disease together.
GSK is a global biopharma company with a purpose to unite science, technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade, as a successful, growing company where people can thrive. We get ahead of disease by preventing and treating it with innovation in specialty medicines and vaccines. We focus on four therapeutic areas: respiratory, immunology and inflammation; oncology; HIV; and infectious diseases – to impact health at scale.
People and patients around the world count on the medicines and vaccines we make, so we’re committed to creating an environment where our people can thrive and focus on what matters most. Our culture of being ambitious for patients, accountable for impact and doing the right thing is the foundation for how, together, we deliver for patients, shareholders and our people.
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