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Bothell, Washington, United States
Hybrid
At Pfizer, we're investing in the future of AI-enabled drug discovery.
This role is about more than using AI to improve existing ways of working. We are building a new operating model in which small, highly capable teams combine human expertise with AI to achieve outcomes and move at a pace that previously required much larger organizations.
We are looking for people who want to help invent and champion that model: individuals willing to rethink how work is organized, how problems are decomposed, what can be delegated to intelligent systems, and how humans and AI work together most effectively. Successful candidates will use AI not simply as a productivity tool, but as a means to fundamentally transform how scientific and technical work gets done—and will help others across R&D adopt these new ways of working.
Why This Role Is Different
Own Meaningful Problems
You'll own critical AI capabilities from architecture through production deployment. Rather than contributing to isolated components, you'll lead the design and delivery of end-to-end systems that directly enable scientific discovery.
Work Where AI Meets Real-World Impact
The systems you build will support researchers tackling some of the toughest challenges in medicine, helping accelerate insights across discovery, development, and translational science.
Operate at the Frontier of AI
You will work across technologies and domains including:
Accelerate Your Growth
You'll work alongside experts in AI, engineering, computational biology, and drug discovery while taking on increasing technical ownership and influence.
Build, Ship, Learn, Repeat
We value engineers who can move from ambiguity to execution, convert ideas into working systems, measure outcomes, and continuously improve based on real-world feedback.
The Opportunity
As a Senior Principal AI Research Engineer, you will build the machine learning systems that transform innovative models into secure, reliable, and scalable capabilities for scientists across Pfizer.
This is an intermediate-level engineering role with significant technical ownership.
You will:
Success in this role requires strong engineering fundamentals, demonstrated experience delivering production systems, and the ability to operate effectively in an environment where science, technology, and business impact intersect.
What You'll Do
Build the AI Systems Behind Tomorrow's Scientific Breakthroughs
Own End-to-End Technical Delivery
Turn Research Into Impact
Make Thoughtful Engineering Tradeoffs
Build Trusted and Responsible AI
Raise the Engineering Bar
Deliver Measurable Outcomes
What Makes You a Strong Fit
Education & Experience
Technical Expertise
You have demonstrated experience:
Engineering Proficiency
You bring strong proficiency in:
You have depth in one or more of the following areas:
Collaboration & Leadership
You have a proven ability to:
Preferred Qualifications
How You'll Succeed
The most successful engineers in this role:
Why Pfizer
AI is becoming a foundational capability across Pfizer's R&D organization.
We are building an environment where exceptional engineers can tackle technically ambitious challenges, work with world-class scientific experts, and contribute to innovations that have the potential to improve lives around the world.
Here, you'll find:
If you want to build production AI at scale while helping shape the future of scientific discovery, this is an opportunity to do the most meaningful work of your career.
Work Location Assignment
This is a hybrid role requiring colleagues to live within commuting distance of a Pfizer location and work on-site an average of 2.5 days per week.
The annual base salary for this position ranges from $139,100.00 to $231,900.00. In addition, this position is eligible for participation in Pfizer’s Global Performance Plan with a bonus target of 17.5% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life’s moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site – U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.

This role is posted in multiple locations. If you are applying for the role in an secondary job posting location where pay transparency regulations apply, your Talent Advisor will share the local pay information with you during the first interview.


Relocation assistance may be available based on business needs and/or eligibility.
Candidates must be authorized to be employed in the U.S. by any employer.
U.S. work visa sponsorship (such as TN, O-1, H-1B, etc.) is not available for this role now or in the future.
Sunshine Act
Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider’s name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.
EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.
Pfizer endeavors to make www.pfizer.com/careers accessible to all users. If you would like to contact us regarding the accessibility of our website or need assistance completing the application process and/or interviewing, please email disabilityrecruitment@pfizer.com. This is to be used solely for accommodation requests with respect to the accessibility of our website, online application process and/or interviewing. Requests for any other reason will not be returned.
To learn more about acceptable and prohibited uses of AI during the recruitment process, please review our candidate AI-use guidelines available on Pfizer Careers.
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