We are seeking a skilled and motivated Senior Scientist to join our research team focused on innovative oligonucleotide therapeutics strategies. The Senior Scientist will lead projects to develop novel oligonucleotide delivery methods and optimize approaches for oligonucleotide therapeutics quantification across diverse biological matrices; will collaborate across multidisciplinary teams and participate in strategic planning. Responsibilities include mentoring junior scientists, managing laboratory resources, and preparing scientific reports and presentations.
The ideal candidate will have a solid base in molecular biology, nucleic acid technologies, and antibody engineering, with a consistent track record to drive innovation in oligonucleotide-related fields. This role offers the chance to create impactful discoveries in oligonucleotide-based therapeutics.
In this role, a typical day might include the following:
· Developing and applying in vitro and in vivo strategies to improve oligonucleotide delivery efficiency; evaluating and optimizing delivery modalities (e.g., conjugates, nanoparticles); assessing uptake and target gene knockdown in relevant cellular and animal models; troubleshooting delivery barriers; and integrating pharmacokinetic and bio-distribution data with chemistry and in vivo teams to refine approaches.
· Designing and implementing in vitro and in vivo oligonucleotide tracing for advanced detection and analysis; collaborating on labeling techniques (e.g., fluorescent, radioactive, enzymatic tags); establishing sensitive detection protocols; analyzing tissue and cellular distribution; applying quantitative assays to monitor oligonucleotide fate and function; and interpreting complex data to inform therapeutic development.
· Exploring new directions in oligonucleotide technology development, including novel chemical modifications, targeting strategies, and combination therapies; staying current with advancements; proposing innovative project ideas; conducting proof-of-concept experiments; and collaborating with cross-functional teams to translate findings into next generation platforms.
This job might be for you if you:
· Have validated ability to lead research projects, mentor junior scientists, and work effectively within multidisciplinary teams.
· Are skilled in preparing scientific reports, presentations, and publications, with strong written and verbal communication abilities.
· Are a creative problem solver with a track record of proposing and implementing novel solutions in oligonucleotide therapeutics and related fields.
· Have hands-on experience with mammalian cell culture and working with preclinical animal models for evaluating oligonucleotide delivery and efficacy.
In order to be considered for this role, you must have:
- A PhD - Molecular biology, biochemistry, or related field.
- Research experience in genetics medicine.
- Validated experience and strong proficiency in molecular biology methods, including PCR, qPCR, cloning, and nucleic acid purification; as well as experience in troubleshooting and optimizing protocols.
- Consistent record of strong analytical and quantitative skills, with expertise in quantitative assays (e.g., ELISA, digital PCR, fluorescence-based detection) for analyzing oligonucleotides and proteins in biological samples.
Good understanding in RNAi technologies, experience with optimizing delivery of RNAi molecules to target cells, evaluating knockdown efficiency; familiarity with in vitro and in vivo models to study RNAi-mediated gene regulation, quantitative assays to measure gene expression changes; and experience/skills in protein engineering, particularly in designing and modifying antibodies for improved specificity and affinity are highly preferred.
Experience with antibody-drug conjugates (ADCs), bispecific antibodies, and other formats used for targeted delivery of therapeutics, and understanding of strategies to link antibodies to oligonucleotides or nanoparticles for enhanced cellular uptake and tissue targeting are a plus.
Does this sound like you? Apply now to take your first step towards living the Regeneron Way! We have an inclusive culture that provides comprehensive benefits, which vary by location. In the U.S., benefits may include health and wellness programs (including medical, dental, vision, life, and disability insurance), fitness centers, 401(k) company match, family support benefits, equity awards, annual bonuses, paid time off, and paid leaves (e.g., military and parental leave) for eligible employees at all levels! For additional information about Regeneron benefits in the US, please visit https://careers.regeneron.com/en/working-at-regeneron/total-rewards/. For other countries’ specific benefits, please speak to your recruiter.
Please be advised that at Regeneron, we believe we are most successful and work best when we are together. For that reason, many of Regeneron’s roles are required to be performed on-site. Please speak with your recruiter and hiring manager for more information about Regeneron’s on-site policy and expectations for your role and your location.
Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or parental status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. The Company will also provide reasonable accommodation to the known disabilities or chronic illnesses of an otherwise qualified applicant for employment, unless the accommodation would impose undue hardship on the operation of the Company's business.
For roles in which the hired candidate will be working in the U.S., the salary ranges provided are shown in accordance with U.S. law and apply to U.S.-based positions. For roles which will be based in Japan and/or Canada, the salary ranges are shown in accordance with the applicable local law and currency. If you are outside the U.S, Japan or Canada, please speak with your recruiter about salaries and benefits in your location.
Please note that certain background checks will form part of the recruitment process. Background checks will be conducted in accordance with the law of the country where the position is based, including the type of background checks conducted. The purpose of carrying out such checks is for Regeneron to verify certain information regarding a candidate prior to the commencement of employment such as identity, right to work, educational qualifications etc.
Salary Range (annually)