Senior Scientist DMPK

Does it excite you to work with drug metabolism and pharmacokinetics across peptides, proteins and small molecules, and do you have experience with in vitro ADME assays and liquid chromatography-mass spectrometry (LC-MS)

bioanalysis? If this sounds like you, and you are ready to take on a broad area of responsibilities, then you could be our new colleague.

Your new position
As Senior Scientist DMPK, you will drive DMPK science from early discovery through development, across a range of modalities. You will support the DMPK discovery platforms and oversee studies run both in-house and with external partners. Your work will turn data into clear insights that guide project decisions and support governance milestones. The role stands out through its focus on peptide drugs for obesity and metabolic health, its mix of in-house and external study work, and the chance to shape digital and automation-enabled approaches within DMPK workflows.

We offer exciting responsibilities:

• Drive DMPK/ADME science in drug discovery and development across modalities such as small molecules, peptides and protein therapeutics
• Support DMPK discovery platforms spanning LC-MS bioanalysis, pharmacokinetics, metabolic stability, biotransformation, drug-drug interactions, permeability and transporter studies
• Oversee internal and external DMPK studies from study design through assay development, data interpretation and reporting, ensuring scientific quality, adherence to timelines and complete documentation
• Deliver integrated ADME summaries and high-quality data packages that support project teams, governance milestones and external-facing documentation
• Contribute to continuous improvement by adopting efficient, digital and automation-enabled approaches within DMPK workflows

Your profile
You are a collaborative and curious scientist who combines scientific depth with a keen eye for quality and detail. You communicate clearly with colleagues across disciplines and with external partners, and you take ownership of results from study design to final report. You enjoy translating complex data into practical guidance for project teams.

Deep expertise in every area below is not required. You bring:

• A PhD in pharmaceutical sciences, biochemistry, chemistry or a related scientific field, or a Master’s degree combined with more extensive experience
• Several years of relevant post-degree experience in DMPK/ADME
• A track record in pharmacokinetic study design and data interpretationand in feeding DMPK results back to project teams to guide structural optimization and improve the DMPK properties of small molecules and other modalities such as peptides, antibodies and conjugates
• Experience with in vitro ADME assays such as metabolic stability, metabolite identification, drug-drug interactions, absorption/permeability and transporters
• A solid background in bioanalysis and assay development using LC-MS
• Experience working in cross-functional teams and with external contract research organization (CRO) partners, including scientific oversight with an eye for high-quality execution
• Experience with regulatory-relevant DMPK documentation (e.g., support for Investigational New Drug (IND) and Clinical Trial Application (CTA) submissions), and with digital and automation-enabled DMPK workflows is an advantage

Your new team
You will join the Global DMPK department within Pharmacokinetics, Immunogenicity and Bioanalytical Sciences, working closely with cross-functional R&D stakeholders (e.g., Discovery, Translational, Toxicology, Clinical Pharmacology, and Regulatory) to shape study strategies, interpret data, and communicate DMPK risks and recommendations.

Let’s bond and be bold
We have a unique culture, characterized by excellent teamwork and strong engagement across the organization. And we want you to help us strengthen this culture. Making bonds is at the core of everything we do. From discovering and developing the best new peptide drugs for patients, to engaging with our partners or connecting with each other. We bond through curiosity and playfulness as a team, allowing ourselves to challenge common thinking and drive future innovation. Join us and let’s bond and be bold.

Interested in bonding with us? Then please apply no later than December 19, 2026, or as soon as possible. The applications will be reviewed as they come in. While a cover letter is not required, please include a few sentences in your CV explaining your motivation for applying.

We are committed to an inclusive recruitment process and welcome applications from all job applicants.

About Zealand Pharma A/S
Zealand Pharma A/S (Nasdaq: ZEAL) is a biotechnology company focused on advancing medicines for obesity and metabolic health. Combining more than 25 years of peptide R&D expertise with a proprietary data platform that leverages advanced data-driven and AI/ML approaches, Zealand Pharma aims to lead a new era in obesity and metabolic health. To date, more than ten Zealand Pharma-invented drug candidates have entered clinical development, of which two products have reached the market and three candidates are in late-stage development. The Company has collaborations with global pharmaceutical and biotechnology partners for research, development, and commercialization. Founded in 1998, Zealand Pharma is headquartered in Copenhagen, Denmark, with a U.S. presence in Boston, Massachusetts. Learn more at www.zealandpharma.com.

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