Senior Scientist – Downstream Process Development & Resin Design-In

Work Schedule

Standard (Mon-Fri)

Environmental Conditions

Adherence to all Good Manufacturing Practices (GMP) Safety Standards, Laboratory Setting, Some degree of PPE (Personal Protective Equipment) required (safety glasses, gowning, gloves, lab coat, ear plugs etc.)

Job Description

As part of the Thermo Fisher Scientific team, you’ll discover meaningful work that makes a positive impact on a global scale. Join our colleagues in bringing our Mission to life every single day to enable our customers to make the world healthier, cleaner and safer. We provide our global teams with the resources needed to achieve individual career goals while helping to take science a step beyond by developing solutions for some of the world’s toughest challenges, like protecting the environment, making sure our food is safe or helping find cures for cancer.

Location: On-site Plainville, MA. Relocation assistance is NOT provided. 

• Must be legally authorized to work in the United States without sponsorship.
• Must be able to pass a comprehensive background check, which includes a drug screening.

How Will You Make an Impact?

Our new Bioprocess Design Center is an innovative facility dedicated to demonstrating and training customers on our innovative single-use technologies, Upstream and Downstream solutions, cell culture media, cell lines, resin and analytical offerings. We are seeking an experienced Senior Scientist – Downstream Process Development & Resin Design-In to lead chromatography process development, resin selection, and customer process-design activities.

This is a senior, customer-facing technical role combining deep downstream process expertise with commercial and strategic acumen. The successful candidate will lead the BDC’s Resin Design-In capability, partnering directly with biopharmaceutical customers to understand purification challenges, develop data-driven solutions, and translate experimental results into scalable process recommendations.

Working across customers, commercial teams, R&D, product management, and applications, this individual will serve as a trusted technical advisor and chromatography subject-matter expert, using scientific evidence to accelerate customer decision-making and adoption of Thermo Fisher downstream technologies.

What Will You Do?
Downstream Process Development & Technical Leadership

• Lead resin selection, screening, benchmarking, and chromatography process-development programs across capture, intermediate, and polishing operations.
• Independently design and execute studies evaluating resin performance, dynamic binding capacity, breakthrough behavior, residence time, loading, wash/elution conditions, impurity clearance, and process robustness.
• Apply DoE and data-driven approaches to optimize processes and develop technically defensible resin recommendations.
• Develop scale-down models and scale-up strategies supporting translation from laboratory development to manufacturing.
• Serve as a downstream chromatography SME and mentor scientists and engineers in experimental design, troubleshooting, data interpretation, and scale-up.

Customer & Commercial Engagement

• Serve as a senior technical advisor to customers evaluating chromatography and downstream processing solutions.
• Lead technical discovery discussions and translate complex customer challenges into structured process-development programs.
• Present experimental strategies, results, and recommendations to customer scientists, engineers, and technical leadership.
• Partner with commercial and field teams on strategic opportunities, technical workshops, customer demonstrations, and pre-sales activities.
• Translate technical performance into customer value related to productivity, scalability, robustness, operational efficiency, and risk reduction.

Resin Design-In Capability & Innovation

• Own and advance the BDC’s Resin Design-In capability, including standardized workflows for resin screening, process optimization, data analysis, and reporting.
• Develop reusable technical tools, decision frameworks, application data, and customer-facing technical packages.
• Partner with R&D and product management to translate customer insights and experimental evidence into product, application, and workflow improvements.
• Collaborate across upstream, filtration, analytical, automation, and process-modeling teams to develop integrated and next-generation bioprocess solutions.
• Identify emerging customer needs and industry trends that can inform new BDC capabilities, services, and commercial opportunities.

How Will You Get Here?

• B.S. in Chemical Engineering, Biochemical Engineering, Biochemistry, Biotechnology, or related discipline with 8+ years of relevant industry experience; M.S. with 6+ years; or Ph.D. with 3+ years, or equivalent experience.
• Significant hands-on experience in downstream bioprocess development and chromatography process optimization for biologics.
• Strong knowledge of chromatography fundamentals including resin selection, binding capacity, breakthrough behavior, residence time, column sizing, and process scale-up.
• Experience with multiple chromatography modalities such as Protein A affinity, ion exchange, mixed-mode, or hydrophobic interaction chromatography.
• Demonstrated ability to independently design experiments, analyze complex data, troubleshoot process performance, and translate results into actionable recommendations.
• Strong technical communication and presentation skills with the ability to engage both scientific and business stakeholders.
• Experience in a customer-facing technical, applications, consulting, or technical sales-support role strongly preferred.
• Experience with DoE, process characterization, competitive resin benchmarking, and/or scale-down model development preferred.

We offer competitive remuneration, annual incentive plan bonus scheme, healthcare, company 401k, and a range of employee benefits! Thermo Fisher Scientific offers employment with an innovative, forward-thinking organization, and outstanding career and development prospects. We offer an exciting company culture that stands for integrity, intensity, involvement, and innovation. 

Thermo Fisher Scientific is an EEO/Affirmative Action Employer and does not discriminate based on race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability, or any other legally protected status. We will ensure that individuals with disabilities are provided a reasonable accommodation to participate in the job application or interview process, to perform critical job functions, and to receive other benefits and privileges of employment. Please contact us to request an accommodation. 

Compensation and Benefits

The salary range estimated for this position based in Massachusetts is $115,000.00–$150,000.00.

This position may also be eligible to receive a variable annual bonus based on company, team, and/or individual performance results in accordance with company policy. We offer a comprehensive Total Rewards package that our U.S. colleagues and their families can count on, which includes:

• A choice of national medical and dental plans, and a national vision plan, including health incentive programs

• Employee assistance and family support programs, including commuter benefits and tuition reimbursement

• At least 120 hours paid time off (PTO), 10 paid holidays annually, paid parental leave (3 weeks for bonding and 8 weeks for caregiver leave), accident and life insurance, and short- and long-term disability in accordance with company policy

• Retirement and savings programs, such as our competitive 401(k) U.S. retirement savings plan

• Employees’ Stock Purchase Plan (ESPP) offers eligible colleagues the opportunity to purchase company stock at a discount

For more information on our benefits, please visit: https://jobs.thermofisher.com/global/en/total-rewards