About Stylus Medicine:
Stylus Medicine is developing transformative in vivo genetic medicines to unlock cures. Stylus combines engineered recombinases with non-viral delivery to specifically encode therapeutics. The company’s approach is versatile and modular, with potential therapeutic application across oncology, autoimmune, genetic diseases, and beyond.
About the Role:
Stylus Medicine is seeking a highly motivated and collaborative Senior Scientist to join our in vivo Pharmacology team. This role will be responsible for leading NHP studies, including working closely with CROs to manage studies, contribute to protocol writing and design, obtain, quality control, analyze and interpret data, lead investigative technical troubleshooting, ensure consistency in execution across studies, and create detailed and thorough study summaries. Reporting to the Director of in vivo Pharmacology and working closely with cross-functional teams, this is a unique opportunity to contribute to foundational development in a fast-paced, cutting-edge biotech environment and advance the development of transformative in vivo genetic medicines.
Key Responsibilities & Accountabilities:
- Design NHP study protocols and lead CRO communication
- Analyze, interpret, and communicate NHP study data, including flow cytometry analysis, cytokine analysis and other ex vivo readouts, to inform project direction and decision-making
- Evaluate data for consistency and follow-up as needed, working closely with CROs to optimize study protocols
- Investigate and interpret biological findings from NHP studies
- Manage NHP study test article generation and transfer in collaboration with internal cross-functional teams
- Conduct experiments to optimize protocols for CRO transfer or investigate biological findings
- Generate and manage study documentation, including protocols and study reports
- Effectively communicate findings to internal teams.
- Maintain detailed and accurate laboratory records in compliance with data integrity and documentation standards
- Limited travel may be required
Qualifications & Skills:
- PhD in Pharmacology, Immunology, Immuno-oncology, or a related field with 4-6 years of relevant industry or academic experience, or a Master's degree with 8+ years of experience
- Demonstrated experience with ex vivo analytical techniques, such as flow cytometry, cytokine analysis, and ddPCR
- Demonstrated ability to design, execute, interpret, and troubleshoot immunology-related in vivo studies and to coordinate the activities of multiple study contributors
- Experience coordinating with animal vendors, CROs or external collaborators
- Prior experience with NHP studies is preferred
- Experience in designing experiments to address PK/PD/biodistribution/tox relationships is a plus
- Experience with LNP or CART delivery technologies and genetic medicine platforms is a plus
- Experience with T cell or PBMC isolation and handling from peripheral blood, engineering, and downstream immunological or molecular assays
- Demonstrated ability to work independently in a laboratory setting, learn new techniques, multitask effectively, and maintain meticulous records
- Demonstrated proficiency in documenting and maintaining an organized lab notebook, lab inventory, and experimental results
- Excellent organizational and communication skills, with a team-first mindset and the ability to convey technical information
- Analytical thinker with the ability to distill complex data into clear, actionable insights
Pay Range: $160,000 - $175,000
