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South San Francisco, California, United States
Onsite
Who We Are
Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company whose mission is to harness advanced technologies and model systems to increase our understanding of the biology that controls human aging. Calico will use that knowledge to devise interventions that enable people to lead longer and healthier lives. Calico’s highly innovative technology labs, its commitment to curiosity-driven discovery science and, with academic and industry partners, its vibrant drug-development pipeline, together create an inspiring and exciting place to catalyze and enable medical breakthroughs.
The Calico Postdoctoral Fellowship Program
We are seeking ambitious early career scientists to join us in our mission to increase our understanding of the biology that controls human aging. This is a unique opportunity for individuals to distinguish themselves in aging research, deepen scientific training, and develop research independence.
The Postdoctoral Fellowship is a fixed-term educational assignment (three years with a potential fourth year extension) with rolling start dates. Postdoctoral Fellows are fully integrated into Calico's labs and community.
The program is designed to train individuals to become independent investigators in an academic or industry setting upon successful completion of the assignment. Fellows will receive regular feedback and guidance from their mentor(s) and participate in a formal annual review process to review project progress and individual performance and provide career coaching.
Responsibilities
Position Requirements
The successful candidate will demonstrate characteristics valued across Calico's programs, including being a self-motivated team player, detail-oriented, extremely organized, and comfortable working on complex problems.
Application Requirements
The Postdoctoral Fellowship has four application components:
The estimated base salary for this role is $95,000. More information on our postdoctoral fellowship program can be found here.
About the Hahn Lab
We investigate why specific cells in the brain, such as the resident immune cells, microglia, are among the earliest and most vulnerable sites of aging, and how this vulnerability contributes to neurodegeneration. Our central mission is to decode and ultimately reprogram the brain’s immune system to dampen or reverse age‑related neuroinflammation.
The group has established a rich arsenal of novel in vitro and in vivo discovery platforms. These include scalable heterochronic myeloid cell replacement paradigms that swap native microglia with CRISPR‑ready donor cells across young and old brains, and a new protocol for generating neuroimmune cells in vitro at a very large scale. These novel approaches are complemented by world-class CNS research equipment including custom FACS instruments, bespoke electrophysiology setups and 2 Photon in vivo imaging suites. We welcome proposals that aim to decode altered cell-cell signaling in the CNS through scalable in vitro or ex vivo experimentation. The ideal candidate is a highly motivated innovator with a strong collaborative streak and a drive to take discoveries from cellular models to whole organisms.
Publications from the group include:
