Want to know if this job is worth applying to?
San Francisco, California, United States
Onsite
We have an opportunity for a Postdoctoral Scientist to join the Martens lab at the University of California, San Francisco. Dr. Hanna Martens investigates how aging disrupts the tissue microenvironment by altering extracellular matrix organization, mechanical signaling, and cell-cell communication. We seek to understand how these changes influence cell behavior, tissue homeostasis, and regenerative capacity, with the long-term goal of developing strategies to restore tissue function and promote healthy aging. By integrating molecular genetics, quantitative imaging, single-cell and spatial genomics, bioengineering, and engineered extracellular matrix mimetics with advanced 3D cell culture systems, we aim to uncover fundamental mechanisms of aging and develop strategies to restore tissue function and promote healthy aging. Our laboratory combines mouse genetics, genome engineering, advanced microscopy, quantitative image analysis, single-cell and spatial multi-omics, biomaterials, and engineered in vitro model systems to investigate how the aging microenvironment regulates cell behavior and tissue function. More information about the lab and their work can be found by visiting https://martenslab.ucsf.edu/
About the Postdoctoral Scientist role:
We are seeking highly motivated scientists with a strong record of research accomplishment, intellectual curiosity, and the potential to develop into independent investigators. Applicants with expertise in aging biology, cell and molecular biology, stem cell biology, developmental biology, extracellular matrix biology, mechanobiology, immunology, bioengineering, biomaterials, or related disciplines are encouraged to apply. We also welcome candidates with strong computational backgrounds and experience analyzing single-cell, spatial, or other high-dimensional biological datasets.
Current research directions include:
Mechanisms of tissue aging and regeneration
Extracellular matrix deterioration, mechanosignaling, and fibroblast biology
Stem cell niches and intercellular communication during aging
Engineering ECM-mimetic microenvironments and regenerative strategies to restore tissue function
Application Instructions:
Please include the following items as part of your application:
A cover letter describing your research accomplishments, scientific interests, and career goals
Curriculum vitae
Contact information for three professional references
We welcome applicants from diverse scientific backgrounds who are excited to answer fundamental questions in aging biology and develop innovative approaches to restore tissue function across the lifespan.
What we provide:
An intellectually stimulating, collaborative, and supportive research environment
Stable research support through HHMI
Opportunities to pursue ambitious, high-impact scientific questions
Individualized scientific and career mentorship
Strong support for fellowship and grant applications
Opportunities to mentor students and junior scientists
Access to world-class genomics, imaging, bioengineering, and computational core facilities at UCSF
Extensive collaborations across UCSF and the broader Bay Area scientific community
A competitive salary and comprehensive benefits package
What you’ll do:
Develop and lead independent research projects
Design, execute, and interpret rigorous experiments
Work collaboratively within an interdisciplinary research environment
Present research at laboratory meetings, seminars, and international conferences
Publish in leading scientific journals
Pursue fellowship and career development opportunities
Mentor graduate students and other trainees
Contribute to a collaborative, rigorous, and supportive laboratory culture
What you bring:
A Ph.D., M.D./Ph.D., or equivalent doctoral degree in cell biology, molecular biology, developmental biology, aging biology, bioengineering, computational biology, or a related discipline, completed before the anticipated start date
A strong publication record demonstrating scientific creativity, technical excellence, and scientific rigor
Excellent written and verbal communication skills
The ability to work both independently and collaboratively
A commitment to scientific integrity, mentorship, and a positive laboratory culture
Physical Requirements
Remaining in a normal seated or standing position for extended periods of time; reaching and grasping by extending hand(s) or arm(s); dexterity to manipulate objects with fingers, for example using a keyboard; communication skills using the spoken word; ability to see and hear within normal parameters; ability to move about workspace. The position requires mobility, including the ability to move materials weighing up to several pounds (such as a laptop computer or tablet).
Persons with disabilities may be able to perform the essential duties of this position with reasonable accommodation. Requests for reasonable accommodation will be evaluated on an individual basis.
Please Note:
This job description sets forth the job’s principal duties, responsibilities, and requirements; it should not be construed as an exhaustive statement, however. Unless they begin with the word “may,” the Essential Duties and Responsibilities described above are “essential functions” of the job, as defined by the Americans with Disabilities Act.
#LI-LL1
Compensation and Benefits
Our employees are compensated from a total rewards perspective in many ways for their contributions to our mission, including competitive pay, exceptional health benefits, retirement plans, time off, and a range of recognition and wellness programs. Visit our Benefits at HHMI site to learn more.
Hiring Pay Range
$70,000.00 - $80,500.00Pay Type:
Annual

The posted range reflects HHMI’s good faith estimate of the anticipated hiring salary range for this role at the time of posting. Actual hiring compensation is determined by a candidate’s qualifications, experience, and internal equity.
HHMI is an Equal Opportunity Employer
We use E-Verify to confirm the identity and employment eligibility of all new hires.