Career Category
Research
Job Description
Principal Scientist - Pharmacokinetics and Drug Metabolism (Small molecule In vitro ADME group lead)
Live
What you will do
Let’s do this. Let’s change the world. In this role we are seeking a highly motivated scientist to lead a group of in vitro ADME scientists in Pharmacokinetics and Drug Metabolism (PKDM) team at our upcoming research facility in India. The successful candidate will bring strong hands-on expertise in in vitro ADME assays, high-throughput screening, and a strong desire to involve in mechanistic ADME assay development to support small molecule drug discovery projects. This role requires both scientific excellence and team management skills to foster collaboration, innovation, and operational efficiency. In this role, your core responsibilities include:
- Involve and mentor a team of scientists in the design, execution, and interpretation of in vitro ADME studies
- Develop, optimize, validate, and implement mechanistic in vitro assays to characterize drug metabolism, transporter interactions, and drug–drug interaction (DDI) risk
- Design, establish, and validate robust high-throughput screening workflows to support compound profiling and lead optimization efforts
- Oversee the execution and interpretation of a comprehensive suite of in vitro ADME assays, including:
- Metabolic stability assessments using liver microsomes, S9 fractions, and hepatocytes
- Binding assays
- CYP450 inhibition and induction studies
- Transporter uptake and efflux assays
- In vitro drug–drug interaction (DDI) evaluations
- Manage and maintain cell culture platforms supporting ADME studies, including primary hepatocytes, immortalized cell lines, and transporter-transfected cell systems, ensuring model suitability and reproducibility
- Supervise permeability and absorption studies using established in vitro models to assess compound absorption potential
- Ensure data quality, integrity, reproducibility, and timely delivery of results across all in vitro ADME activities, in alignment with internal standards and project timelines
- Ensure compliance with applicable regulatory guidelines, safety requirements, and internal quality systems, maintaining thorough and audit-ready documentation
- Develop team members, fostering a culture of scientific rigor, continuous improvement, and innovation
Basic Qualifications:
Doctorate degree PhD OR PharmD OR MD [and relevant post-doc where applicable] and xx years of directly related experience
Or
Master’s degree and xx years of directly related experience
Or
Bachelor’s degree and xx years of directly related experience
Preferred Qualifications:
- PhD in Pharmacokinetics, Pharmaceutical Sciences, or related fields
- Strong hands-on experience in developing mechanistic in vitro ADME models (e.g. enzyme kinetics, DDI and transporter assays etc) and interpreting complex datasets
- Proven track record in high-throughput screening and assay automation
- Team management skills
- Excellent communication, collaboration, and problem-solving abilities
- Strong publication or project track record in ADME/DMPK research is a plus
.
