Want to know if this job is worth applying to?
Dallas, Texas, United States
Onsite
The Howard Hughes Medical Institute (HHMI) advances the discovery and sharing of scientific knowledge to benefit us all. As a biomedical research organization and philanthropy, HHMI supports a vibrant community of academic researchers, educators, students, and professionals. Together, we're unlocking the fundamentals of biology and building an open, inclusive future for science.
Lab Overview
The Orth Laboratory, led by HHMI Investigator Dr. Kim Orth at UT Southwestern Medical Center in Dallas, Texas, investigates the molecular mechanisms by which pathogenic bacteria manipulate host cell signaling and immune responses. The lab's research integrates microbiology, biochemistry, cell biology, structural biology, and animal models to understand host-pathogen interactions at the molecular level — with the goal of gaining novel molecular insight into eukaryotic signaling systems. For more information, visit https://labs.utsouthwestern.edu/orth-lab
About the Role
We are seeking an expert structural biologist to join the Orth Lab as a Research Specialist II at UT Southwestern Medical Center. This is an excellent opportunity for an accomplished scientist with a strong publication record in CryoEM and/or X-ray crystallography to own independent research projects, serve as the lab's structural biology resource, and mentor other lab members. The ideal candidate brings a full structural biology toolbox, deep expertise in membrane proteins or larger molecular structures, and a passion for advancing research at the intersection of structural biology and molecular pathogenesis.
Application Instructions
Interested candidates should submit the following materials directly through the HHMI Careers portal:
What We Provide
What You'll Do
What You Bring
Required:
Preferred:
Physical Requirements
Remaining in a normal seated or standing position for extended periods of time; reaching and grasping by extending hand(s) or arm(s); dexterity to manipulate objects with fingers, for example using a keyboard; communication skills using the spoken word; ability to see and hear within normal parameters; ability to move about workspace. The position requires mobility, including the ability to move materials weighing up to several pounds (such as a laptop computer or tablet). Work may involve possible exposure to malodorous vapors, low dose radiation, contamination by toxic chemicals and acids and presence of carcinogenic substances or other hazardous materials.
Persons with disabilities may be able to perform the essential duties of this position with reasonable accommodation. Requests for reasonable accommodation will be evaluated on an individual basis.
Please Note:
This job description sets forth the job’s principal duties, responsibilities, and requirements; it should not be construed as an exhaustive statement, however. Unless they begin with the word “may,” the Essential Duties and Responsibilities described above are “essential functions” of the job, as defined by the Americans with Disabilities Act.
#LI-JH1
Compensation and Benefits
Our employees are compensated from a total rewards perspective in many ways for their contributions to our mission, including competitive pay, exceptional health benefits, retirement plans, time off, and a range of recognition and wellness programs. Visit our Benefits at HHMI site to learn more.
Hiring Pay Range
$79,738.00 - $99,673.00Pay Type:
Annual

The posted range reflects HHMI’s good faith estimate of the anticipated hiring salary range for this role at the time of posting. Actual hiring compensation is determined by a candidate’s qualifications, experience, and internal equity.
HHMI is an Equal Opportunity Employer
We use E-Verify to confirm the identity and employment eligibility of all new hires.
.png?1742563296){kind=logo}