What can we offer you?
Apart from job satisfaction, we can offer you:
HEALTH
YOURSELF
WEALTH
We are seeking a motivated and skilled Scientist I to support our invivo imaging studies using small animal models. This role is central to our preclinical research team and involves hands-on work with nuclear medicine (PET/SPECT), computed tomography (CT), and magnetic resonance imaging (MRI). The successful candidate will play a key role in project leadership, with the opportunity to oversee staff and lab spaces. They will also provide technical support across a range of in vivo disease models, perform dosing and surgical procedures, and contribute to team leadership by mentoring junior staff.
This position offers an exciting opportunity to evolve into a strategic leadership role within a fast-paced, collaborative research environment. Whether leading a small team or contributing as a senior individual contributor, you'll have the autonomy to drive research excellence and help shape the future of preclinical imaging studies.
Key Responsibilities
Team Leadership & Staff Development
- Lead or support day-to-day activities within the invivo team, ensuring alignment with project timelines and goals.
- May oversee and develop junior staff (2-4 members) provide training and technical guidance as needed.
- Contribute to the management and optimization of laboratory space, including equipment and supply maintenance.
- Develop, write and enforce laboratory-specific standard operating procedures (SOP’s)
- Evaluate study protocols and collaborate with Discovery Research teams during protocol development.
- Liaise with IACUC and internal stakeholders to ensure compliance with animal use protocols (AUP’s)
- Lead onboarding and integration of new team members.
Study Support & Execution
- Participate in protocol development and review with Discovery Research and cross-functional teams.
- Assist in coordinating study scheduling and establish timelines for protocol execution.
- Execute a wide range of study types including:
- Efficacy, biodistribution, pharmacokinetics, toxicokinetic, and xenograft models.
- Perform dosing and surgical procedures such as:
- IV, IP, SC, IM, PO administrations
- Perfusion, tissue resection, microdissection
- Biological sampling (blood, CSF, organs)
- Survival surgery and CNS administration (preferred but not required)
- Assist in image acquisition (PET, SPECT, CT, MRI) and related procedures.
- Handle radioactive and BSL2 materials, including sample processing, gamma counting, and proper waste disposal.
- Ensure strict adherence to laboratory SOPs and regulatory guidelines (IACUC, radiation safety, lab safety).
- Ensure accurate data collection, analysis and reporting.
- Maintain complete and clear laboratory records.
- Monitor and report on animal health in collaboration with attending veterinarian.
- Represent in vivo operations in meetings and cross-functional communications.
Functional Competencies (Technical knowledge/Skills)
- Some understanding of biology, pharmacology, or small animal imaging in the context of pharmaceutical research
- Ability to multi-task
- Comfort with various computer operating systems and programs
- Strong written and oral communication skills
- Occasional weekend and after-hours work as needed
- Ability to lift 50 pounds
Highly Desired Competencies
- Strong proficiency in IV dosing and minor surgical procedures
- Microdissection of specific tissues (e.g., lymph nodes, brain sections)
- Hands-on experience in a preclinical imaging environment
Experience, Education, and Certifications
- Bachelor’s degree in Biology, Animal Science, or related field, with 7+ years of relevant in vivo research experience or higher degree with 5+ years of relevant in vivo research experience.
- Demonstrated experience mentoring laboratory staff.
- Competence with computer systems and laboratory data platforms.
- Ability to lift up to 50 pounds.
- Availability to work occasional weekends as required.
This role is based in the Perceptive office/lab located in Needham, MA. The annual base salary range for this role is $65,305-$121,287. This range represents the anticipated initial annual salary and may vary depending on several factors including the candidate’s experience and skills and may be subject to market rate adjustment.
