Scientist II Interventional Oncology

At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at jnj.com.

As guided by Our Credo, Johnson & Johnson is responsible to our employees who work with us throughout the world. We provide an inclusive work environment where each person is considered as an individual. At Johnson & Johnson, we respect the diversity and dignity of our employees and recognize their merit.

Job Function:

Discovery & Pre-Clinical/Clinical Development

Job Sub Function:

Biological Research

Job Category:

Scientific/Technology

All Job Posting Locations:

Spring House, Pennsylvania, United States of America

Job Description:

About Innovative Medicine

Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.

Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.

Learn more at https://www.jnj.com/innovative-medicine

An internal pre-identified candidate for consideration has been identified. However, all applications will be considered.

We are searching for the best talent for a Scientist II Interventional Oncology to join our Discovery Biology team based in Spring House, PA.

The successful candidate will join a dynamic, multidisciplinary team of scientists in exploratory immuno-oncology, playing a key role in the evaluation and understanding of new drug concepts in vivo and in vitro.

Responsibilities:

• Execute in vivo pharmacology experiments end-to-end, including tumor cell culture, tumor cell implantation, dosing, and handling of investigational drugs (including chemotherapeutics), tumor volume measurements, and collection of tissues/tumors for downstream analysis
• Monitor ongoing in vivo experiments on a daily basis and collaborate closely with other scientists and SIS staff/Veterinary teams (VETs) to ensure animal welfare and health monitoring
• Assist the team with the planning, design, and execution of various in vivo syngeneic and xenograft studies, utilizing established DDI guidelines for in vivo data collection, analysis, and reporting
• Conduct in vitro human and ex vivo mouse immunology experiments, as required, to support the ongoing INTO portfolio or pre-portfolio programs, including assays using cancer cell, myeloid, and T-cell-based co-cultures
• Demonstrate agility and learning flexibility in applying diverse cellular and molecular biology techniques, including cell/organoid assays, FACS, ELISA, MSD, and qRT-PCR
• Support the Discovery Biology team with experimental setup, assay optimization, and data analysis using appropriate statistical methods, and prepare data in presentation-ready formats and for Electronic Lab Notebook (ELN) entry; provide updates in team and discovery meetings
• Maintain detailed experimental records and ensure compliance with all relevant internal and external training requirements
• Work as a team player and support day-to-day activities, including ordering laboratory reagents and supplies, as needed

Qualifications/Experience

Required:

• A minimum of a Bachelor’s degree in Life Sciences (e.g., Biology, Biochemistry, Pharmacology, or Tumor Immunology) with 3 to 5 years of relevant laboratory-based experience in industry, biotech, or an academic setting; alternatively, a Master’s degree (M.S.) with relevant pharmaceutical, biotech, laboratory, or academic experience
• Experience with animal handling in oncology-relevant rodent models, including subcutaneous and orthotopic tumor implantation techniques, dosing, proper handling of therapeutics, tumor measurements, health monitoring, and data collection and analysis
• Experience adhering to animal welfare and compliance regulations
• Experience with drug administration via subcutaneous, intraperitoneal, and intravenous tail vein injections, as well as oral gavage
• Experience with blood collection techniques, including tail vein, saphenous vein, and cardiac puncture
• Experience performing animal autopsy/dissection, microsurgery, perfusion, and tissue collection
• Familiarity with animal use protocols (AUP) and global IACUC policies

Preferred:

• Experience with cell culture of cancer or immune cells
• Experience with bioluminescent imaging, flow cytometry, immunohistochemistry (IHC), and ELISA/MSD
• Strong learning agility and the ability to work across multiple projects

Additional Information:

• This position may require occasional weekend, evening, and holiday dosing and/or animal monitoring
• This is not an exhaustive list of job functions; additional responsibilities may be assigned as needed for various projects

Other Requirements

• Excellent interpersonal skills with the ability to work effectively in a matrixed team environment
• Strong organizational, data management, and record-keeping skills
• Excellent verbal and written communication skills in English
• Employment is contingent upon completion of required laboratory and animal research training courses and maintaining compliance thereafter
• Proficiency in Microsoft Office and GraphPad Prism

Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act. 

Johnson & Johnson is committed to providing an interview process that is inclusive of our applicants’ needs. If you are an individual with a disability and would like to request an accommodation, please contact us via https://www.jnj.com/contact-us/careers or contact AskGS to be directed to your accommodation resource.

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Required Skills:

 

 

Preferred Skills:

Analytical Reasoning, Biological Sciences, Communication, Data Analysis, Data Compilation, Data Savvy, Design of Experiments (DOE), Drug Discovery Development, Execution Focus, Laboratory Experiments, Molecular Diagnostics, Pharmaceutical Microbiology, Product Knowledge, Project Management, Report Writing, Scientific Research, Technologically Savvy, Troubleshooting