Scientist II, In Vivo Translational Sciences

What You Will Contribute To Altos

An exciting opportunity is available for a Scientist to join the In Vivo Translational Sciences team within Drug Discovery and Development Sciences (3DS) at Altos Labs.

We are seeking a dedicated and highly skilled Scientist for our In Vivo Pharmacology Operations. In this role you will be responsible for the full lifecycle of in vivo pharmacology studies — from design and protocol development through execution, analysis, and interpretation — to support the progression of our therapeutic programs. This role demands a solid understanding of in vivo research methodologies and the ability to operate in a complex, fast-moving research environment. 

Responsibilities

• Lead the full lifecycle of in vivo pharmacology studies across multiple projects — providing in vivo pharmacology and physiology expertise from study design and model selection through dosing and in-life monitoring, tissue collection and processing, data analysis, interpretation, and reporting of results to program teams
• Contribute to selection of pharmacodynamic and target-engagement readouts 
• Contribute to building translational strategy by leveraging in vivo research for target validation and candidate progression
• Develop, characterize, and implement new animal models; including models of fibrosis and other age-related pathologies 
• Evaluate and implement new technologies, platforms, and best practices for in vivo research to enhance study efficiency and quality
• Execute studies in both mice and rats, including conducting survival surgeries to establish rodent models using aseptic technique
• Occasionally execute downstream ex vivo analyses 
• Maintain detailed documentation of all studies in the electronic lab notebook to ensure data integrity and traceability
• Collaborate with cross-functional partners across discovery biology, pharmacology and assay sciences, DMPK, and technology development to advance therapeutic programs
• Ensure all in vivo work meets IACUC-approved protocols and uphold the highest ethical standards in study conduct
• Contribute to a team culture that promotes continuous improvement, ownership, professional growth, and inclusion

Who You Are 

• Ph.D. in biological sciences with a minimum of 3-5 years (Scientist) and 6+ years (Sr. Scientist) of industry experience in a drug discovery and development setting 
• Extensive expertise with all aspects of in vivo rodent research (various dosing routes, anesthesia, surgical procedures, necropsy, tissue processing, etc.) in both mice and rats
• Strong commitment to animal welfare and a 3Rs-centered approach to experimental design
• Excellent communication skills for effective collaboration with internal teams and external CRO partners
• Exceptional organizational skills, strong attention to detail, and the ability to work independently and collaboratively in a dynamic environment
• Demonstrate creative thinking and a proactive, solution-oriented mindset; able to design, troubleshoot, and refine complex in vivo studies with resourcefulness and innovation
• High-level problem-solving ability with strong analytical thinking and the capacity to make practical, data-driven decisions
• Hands-on experience with molecular and cell biology techniques (RNA/DNA extraction, PCR, Western blot, ELISA, and small molecule/biologic assays)
• Willingness and ability to work in a lab/vivarium environment for the majority of working hours, including supporting weekend study needs

Preferred Qualifications

• Experience working across diverse therapeutic modalities, including small molecules, biotherapeutics, nucleic acid therapeutics, and gene therapy is highly desirable
• Experience analyzing age-related diseases/deficits in animal models, including fibrosis, inflammation, metabolic disorders or neurodegeneration

The salary range for Redwood City, CA

• Scientist II, In Vivo Pharmacology: $148,400 - $190,300
• Senior Scientist I, In Vivo Pharmacology $171,400 - $219,700

Exact compensation may vary based on skills, experience, and location.

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