Senior Scientist, DMPK (Small Molecule and/or Large Molecule)

Who We Are:

Neurocrine Biosciences is a leading biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs. We are dedicated to discovering, developing and commercializing life-changing treatments for patients with under-addressed neurological, psychiatric, endocrine and immunological disorders. The company's diverse portfolio includes FDA-approved treatments for tardive dyskinesia, chorea associated with Huntington's disease, classic congenital adrenal hyperplasia, hyperphagia in Prader-Willi syndrome, endometriosis* and uterine fibroids*, as well as a robust pipeline including multiple compounds in mid- to late-phase clinical development across our core therapeutic areas. For more than three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions. We relentlessly pursue medicines to ease the burden of debilitating diseases and disorders, because you deserve brave science. For more information, visit neurocrine.com, and follow the company on LinkedIn, X, Facebook and YouTube. (*in collaboration with AbbVie)

About the Role:

We are looking for a collaborative and highly motivated senior scientist to join our biotransformation and metabolism group. The primary role will be to support in vitro and in vivo metabolite identification for multiple discovery and development projects. The ideal candidate should provide subject matter expertise in enzymology and small molecule or large molecule biotransformation/metabolite identification. The candidate will also have the opportunity to represent preclinical development on research and development teams and regularly interface with internal and external colleagues to ensure timely and accurate dissemination of ADME findings.

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Your Contributions (include, but are not limited to):

• Independently conduct in vitro and in vivo metabolite identification studies including (but not limited to) preparing and analyzing samples for LC-MS/MS analysis, processing data and interpretation of data to understand metabolic pathways

• Develop and implement suitable analytical LC separation methods and troubleshooting analytical issues with minimal supervision

• Develop and optimize MS methods to obtain structural characterization of metabolites of interest

• Radioanalysis (14C, 3H, etc.,) and radio-profiling of in vitro and in vivo biological samples for quantitation and identification of metabolites

• Perform routine instrument maintenance, repair and may troubleshoot complex instrument issues

• Writing protocols and reports, compiling, analyzing, and interpreting data

• Ensuring timely delivery of results in line with project schedules

• Prepare data summaries and present results to peers, colleagues, project team and leadership teams

• Possess excellent written and verbal technical communication skills and the demonstrated ability to lead, guide and influence teams in decision making

Requirements:

• BS with 5+ (preferred 10+ years of experience) OR

• MS with 3+ (preferred 5+ years of experience) OR

• PhD in Biochemistry, Drug Metabolism, or closely related discipline (preferred 2+ years of experience in the industrial discovery and development of small and large molecular therapeutics)

• Expertise and working knowledge of biotransformation of small molecules, enzymology and LC-MS/MS methodology

• Experience with handling of biological samples containing radioactivity used in ADME studies

• Experience with isolation of metabolite and NMR a plus

• Ability to balance multiple projects and handle competing responsibilities

• Demonstrate strong communication skills with the ability to integrate diverse perspectives, deliver critical messaging, and influence leaders/key partners

• Collaborative team behaviors and aspiration to build and sustain relationships with R&D customers and the wider scientific community

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Neurocrine Biosciences is an EEO/Disability/Vets employer.

We are committed to building a workplace of belonging, respect, and empowerment, and we recognize there are a variety of ways to meet our requirements. We are looking for the best candidate for the job and encourage you to apply even if your experience or qualifications don’t line up to exactly what we have outlined in the job description.

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The annual base salary we reasonably expect to pay is $110,800.00-$151,000.00. Individual pay decisions depend on various factors, such as primary work location, complexity and responsibility of role, job duties/requirements, and relevant experience and skills. In addition, this position offers an annual bonus with a target of 20% of the earned base salary and eligibility to participate in our equity based long term incentive program. Benefits offered include a retirement savings plan (with company match), paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage in accordance with the terms and conditions of the applicable plans.