Neurocrine Biosciences is a leading biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs. We are dedicated to discovering, developing and commercializing life-changing treatments for patients with under-addressed neurological, psychiatric, endocrine and immunological disorders. The company's diverse portfolio includes FDA-approved treatments for tardive dyskinesia, chorea associated with Huntington's disease, classic congenital adrenal hyperplasia, hyperphagia in patients with Prader-Willi syndrome, endometriosis* and uterine fibroids*, as well as a robust pipeline including multiple compounds in mid- to late-phase clinical development across our core therapeutic areas. For more than three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions. We relentlessly pursue medicines to ease the burden of debilitating diseases and disorders, because you deserve brave science. For more information, visit neurocrine.com, and follow the company on LinkedIn, X, Facebook and YouTube. (*in collaboration with AbbVie)
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Design, execute, and optimize purification processes for antibodies and bioconjugates using a variety of chromatographic and filtration techniques
Purify and formulate antibodies, ADCs, APCs, AOCs, and related bioconjugate modalities to support discovery and preclinical development activities
Characterize purified products using established analytical methods and interpret data to assess product quality, purity, identity, and conjugation attributes
Analyze experimental results, troubleshoot technical challenges, and recommend process improvements to enhance product recovery, purity, and overall process performance
Generate, organize, and communicate scientific data through technical reports, presentations, and electronic laboratory documentation.
Collaborate effectively with scientists across bioconjugation, protein engineering, analytical, and other cross-functional teams to support project objectives
Evaluate and implement new purification and characterization technologies to improve workflow efficiency and product quality
Maintain accurate laboratory records, batch documentation, and inventory in accordance with company procedures and quality standards
Comply with all safety, quality, and operational requirements while contributing to a productive and collaborative laboratory environment
Maintain responsibility for the storage, inventory management, tracking, and distribution of antibodies, bioconjugates, and precursor materials, ensuring compliance with established procedures and supporting efficient execution of research programs
Manage laboratory inventories of consumables, reagents, and chemicals, and coordinate procurement activities in accordance with departmental procedures and established guidelines to ensure efficient laboratory operations
BS/BA degree in biology and 2+ years of relevant experience OR
MS/MA degree in biology and some relevant industry experience preferred OR
PhD or equivalent and some relevant experience
Knowledge of the principles of Biology, Biochemistry, Molecular Biology, Chemical Biology, Bioengineering, or related field
Demonstrated experience in purification of monoclonal/complex antibodies, antibody fragments, recombinant proteins, and/or bioconjugates and understanding of scale-up principles
Knowledge of protein chemistry, antibody structure-function relationships, and bioconjugation principles is a plus
Hands-on experience in preparative and analytical chromatography techniques including affinity chromatography, ion exchange chromatography (CEX and AEX), Hydrophobic interaction chromatography (HIC), size exclusion chromatography (SEC) and mixed-mode/multimodal chromatography
Experience operating and troubleshooting chromatography systems such as ÄKTA Pure, ÄKTA Avant, or equivalent systems
Proficiency with tangential flow filtration (TFF), ultrafiltration/diafiltration (UF/DF), and buffer exchange processes
Experience characterizing proteins and bioconjugates using analytical methods including: SEC-HPLC, HIC-HPLC for DAR determination, Reverse-phase HPLC, UV-Vis spectroscopy, endotoxin testing (LAL or equivalent)
Familiarity with analytical mass spectrometry for intact mass, subunit analysis, and conjugate characterization a plus
Demonstrated ability to analyze, interpret, and present complex purification and characterization data
Experience maintaining laboratory notebooks, batch records, SOPs, and technical reports in compliance with quality standards
Strong organizational skills with the ability to manage multiple projects and competing priorities simultaneously
Ability to independently design experiments, troubleshoot technical issues, and recommend process improvements
Ability to evaluate emerging purification and characterization technologies and implement novel approaches where appropriate
Demonstrated scientific rigor, attention to detail, and commitment to data integrity and reproducibility
Demonstrated ability to maintain a clean, organized, and efficient laboratory environment while managing multiple priorities
Collaborative team player who builds positive working relationships across functional groups and contributes to a productive team culture
Demonstrated ability to work effectively in a highly interactive, fast-paced research environment
Strong sense of ownership, accountability, and follow-through in completing assigned responsibilities
Adaptable and receptive to feedback, with a continuous improvement mindset and eagerness to learn new techniques and technologies
Proactive, approachable, and engaged, with a willingness to actively participate in scientific discussions and team activities
The pay you should reasonably expect to receive is $43.17 - $62.55 per hour. Decisions depend on various factors, such as primary work location, complexity and responsibility of role, job duties/requirements, and relevant experience and skills.
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Neurocrine Biosciences is an EEO/Disability/Vets employer.
We are committed to building a workplace of belonging, respect, and empowerment, and we recognize there are a variety of ways to meet our requirements. We are looking for the best candidate for the job and encourage you to apply even if your experience or qualifications don’t line up to exactly what we have outlined in the job description.